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儿童人群中的格雷夫斯眼病

Graves' Ophthalmopathy in a Paediatric Population.

作者信息

Sadeghi Y, Obéric A, Theintz G, Hamédani M

机构信息

Oculoplastic surgery unit, Jules Gonin Eye Hospital, University of Lausanne, Switzerland.

出版信息

Klin Monbl Augenheilkd. 2017 Apr;234(4):591-594. doi: 10.1055/s-0043-100566. Epub 2017 Mar 22.

Abstract

Graves' disease is an autoimmune disorder leading to hyperthyroidism. It is often associated with ophthalmic manifestations. Graves' disease is reported to be rare in the paediatric population. We performed a retrospective analysis on all patients diagnosed with ophthalmopathy related to Graves' disease at a paediatric age (less than 18 years old) in our institution between 2004 and 2015. Eight patients were identified: 6 females and 2 males. The median age at diagnosis was 11.5 years (range 3-16). Ophthalmic signs were: proptosis (6/8), superficial punctate keratitis (5/8), eyelid retraction (4/8), lagophthalmos (2/8), and oculomotor dysfunction (2/8). No patients showed signs of complication such as ocular hypertension or compressive optic neuropathy. Orbital decompression was performed in one patient in a non-emergency setting. Ophthalmic involvement in Graves' disease is rarely encountered in paediatric patients. Ophthalmologists should be aware of this entity to ensure that patients with thyroid dysfunction are identified at an early point in time.

摘要

格雷夫斯病是一种导致甲状腺功能亢进的自身免疫性疾病。它常伴有眼部表现。据报道,格雷夫斯病在儿科人群中较为罕见。我们对2004年至2015年间在我们机构诊断为儿科年龄(小于18岁)格雷夫斯病相关眼病的所有患者进行了回顾性分析。共确定了8例患者:6名女性和2名男性。诊断时的中位年龄为11.5岁(范围3 - 16岁)。眼部体征包括:突眼(6/8)、浅层点状角膜炎(5/8)、眼睑退缩(4/8)、兔眼(2/8)和动眼功能障碍(2/8)。没有患者出现如高眼压或压迫性视神经病变等并发症迹象。1例患者在非紧急情况下进行了眼眶减压术。格雷夫斯病的眼部受累在儿科患者中很少见。眼科医生应了解这种疾病,以确保甲状腺功能障碍患者能在早期被识别出来。

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