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[2002 - 2013年河南省预防艾滋病母婴传播的效果]

[Effectiveness of prevention of mother to child HIV transmission in Henan province, 2002-2013].

作者信息

Wang Q, Sun D Y, Fan P Y, Ma Y M, Ma N, Si H, Li N, Wang Z

机构信息

Institute of STD/AIDS Control and Prevention, Henan Provincial Center for Disease Control and Prevention, Zhengzhou 450016, China.

Henan Provincial Academy of Medical Science, Zhengzhou 450016, China.

出版信息

Zhonghua Liu Xing Bing Xue Za Zhi. 2017 Mar 10;38(3):359-363. doi: 10.3760/cma.j.issn.0254-6450.2017.03.017.

Abstract

To evaluate the effectiveness of the intervention on preventing mother to child transmission of HIV and identify the influencing factors. The data regarding the pregnant women and their infants were collected, including demographic characteristics, pregnancy and delivery, access to antiviral therapy, HIV infection status at age 18 months and survival of infants between 2002 and 2013 through follow-up, Multivariate logistic regression model were used to identify the influencing factors. By the end of 2013, a total of 8 621 554 pregnant women received HIV test, among them 2 264 were infected with HIV. The positive rate of HIV is 0.03%. The HIV positive rate decreased year by year ((2) =4.871, =0.027). A total of 1 530 infants were born from 2002 to 2013, among them 1 384 survived and 92 died at age of 18 months, and 54 were lost for follow up. Sixty infants were tested to be HIV-positive, 1 324 infants were tested to be HIV-negative. The mother to child transmission rate was 4.34%, the corrective mother to child transmission rate was 6.33%. Receiving HIV prevention service in early pregnancy (=0.26, 95: 0.09-0.77), standardized antiviral therapy (=0.42, 95: 0.21-0.82), artificial feeding (=0.06, 95: 0.02-0.21) might be the main protective factors, episiotomy on delivery (=3.91, 95: 1.74-8.80) might be the risk factors. The HIV tested positive rate remained to be low and decreased year by year in pregnant women in Henan, but the mother to child HIV transmission rate was high. It is necessary to improve the prevention of mother to child HIV transmission.

摘要

评估该干预措施在预防艾滋病母婴传播方面的效果,并确定影响因素。收集了孕妇及其婴儿的数据,包括人口统计学特征、妊娠和分娩情况、抗病毒治疗的获取情况、18个月龄时的艾滋病毒感染状况以及2002年至2013年期间通过随访得出的婴儿存活情况,采用多因素logistic回归模型确定影响因素。截至2013年底,共有8621554名孕妇接受了艾滋病毒检测,其中2264人感染艾滋病毒。艾滋病毒阳性率为0.03%。艾滋病毒阳性率逐年下降((2)=4.871,=0.027)。2002年至2013年共出生1530名婴儿,其中1384名存活,92名在18个月龄时死亡,54名失访。60名婴儿艾滋病毒检测呈阳性,1324名婴儿艾滋病毒检测呈阴性。母婴传播率为4.34%,校正后的母婴传播率为6.33%。孕早期接受艾滋病毒预防服务(=0.26,95%:0.09 - 0.77)、规范抗病毒治疗(=0.42,95%:0.21 - 0.82)、人工喂养(=0.06,95%:0.02 - 0.21)可能是主要保护因素,分娩时会阴切开术(=3.91,95%:1.74 - 8.80)可能是危险因素。河南省孕妇艾滋病毒检测阳性率仍处于较低水平且逐年下降,但母婴艾滋病毒传播率较高。有必要加强艾滋病母婴传播的预防工作。

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