Grothe Matthias, Doppl Karla, Roth Charlotte, Roschka Sybille, Platz Thomas, Lotze Martin
Department for Neurology, University of Greifswald, Germany.
Functional Imaging Unit, Center for Diagnostic Radiology, University of Greifswald, Germany.
Neurosci Lett. 2017 Apr 24;647:117-121. doi: 10.1016/j.neulet.2017.03.016. Epub 2017 Mar 19.
Repetitive unilateral upper limb motor training does not only affect behavior but also increases excitability of the contralateral primary motor cortex (M1). The behavioral gain is partially transferred to the non-trained side. Changes in M1 intracortical facilitation (ICF) might as well be observed for both hand sides. We measured ICF of both left and right abductor pollicis brevis muscles (APB) before and after a two-week period of arm ability training (AAT) of the left hand in 13 strongly right handed healthy volunteers. Performance with AAT-tasks improved for both the left trained and right untrained hand. ICF for the untrained hand decreased over training while it remained unchanged for the left trained hand. Decrease of ICF for the right hand was moderately associated with an increase of AAT-performance for the untrained right hand. We conclude that ICF-imbalance between dominant and non-dominant hand is sensitive to long-term motor training: training of the non-dominant hand results in a decrease of ICF of the dominant hand. The ICF-decrease is associated with a transfer of training-induced improvement of performance from the non-dominant to the dominant hand.
重复性单侧上肢运动训练不仅会影响行为，还会增加对侧初级运动皮层（M1）的兴奋性。行为上的改善会部分转移到未训练的一侧。双手的M1皮层内易化（ICF）也可能会出现变化。我们对13名惯用右手的健康志愿者进行了为期两周的左手手臂能力训练（AAT），并在训练前后测量了左右拇短展肌（APB）的ICF。左手训练任务和右手未训练任务的表现均有所改善。未训练手的ICF在训练过程中降低，而训练的左手ICF保持不变。右手ICF的降低与未训练右手AAT表现的提高适度相关。我们得出结论，优势手和非优势手之间的ICF失衡对长期运动训练敏感：非优势手的训练会导致优势手的ICF降低。ICF的降低与训练诱导的表现改善从非优势手向优势手的转移有关。
