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A New Strategy to Treat Mitochondrial Disease Without Improvement of Mitochondrial Function?

作者信息

Chen Qun, Lesnefsky Edward J

机构信息

Department of Medicine, Division of Cardiology, Pauley Heart Center, Virginia Commonwealth University School of Medicine, Richmond, VA 23298, United States.

Department of Medicine, Division of Cardiology, Pauley Heart Center, Virginia Commonwealth University School of Medicine, Richmond, VA 23298, United States; Department of Biochemistry and Molecular Biology, Virginia Commonwealth University School of Medicine, Richmond, VA 23298, United States; Department of Physiology and Biophysics, Virginia Commonwealth University School of Medicine, Richmond, VA 23298, United States; McGuire VA Medical Center, Richmond, VA 23249, United States.

出版信息

EBioMedicine. 2017 Apr;18:19-20. doi: 10.1016/j.ebiom.2017.03.016. Epub 2017 Mar 14.

DOI:10.1016/j.ebiom.2017.03.016
PMID:28330810
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC5405155/
Abstract
摘要

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EBioMedicine. 2017 Mar;17:75-87. doi: 10.1016/j.ebiom.2017.02.013. Epub 2017 Feb 16.
2
Protection against alcohol-induced neuronal and cognitive damage by the PPARγ receptor agonist pioglitazone.过氧化物酶体增殖物激活受体γ（PPARγ）受体激动剂吡格列酮对酒精诱导的神经元和认知损伤的保护作用。
Brain Behav Immun. 2017 Aug;64:320-329. doi: 10.1016/j.bbi.2017.02.001. Epub 2017 Feb 3.
3
Dynamics of Human Mitochondrial Complex I Assembly: Implications for Neurodegenerative Diseases.人类线粒体复合物 I 组装的动力学：对神经退行性疾病的影响。
Front Mol Biosci. 2016 Aug 22;3:43. doi: 10.3389/fmolb.2016.00043. eCollection 2016.
4
Mitochondrial complex I deficiency increases protein acetylation and accelerates heart failure.线粒体复合物 I 缺陷增加蛋白质乙酰化并加速心力衰竭。
Cell Metab. 2013 Aug 6;18(2):239-50. doi: 10.1016/j.cmet.2013.07.002.
5
Cytoprotection by the modulation of mitochondrial electron transport chain: the emerging role of mitochondrial STAT3.通过调节线粒体电子传递链实现细胞保护：线粒体 STAT3 的新兴作用。
Mitochondrion. 2012 Mar;12(2):180-9. doi: 10.1016/j.mito.2011.08.011. Epub 2011 Sep 10.
6
Neuroprotective role of antidiabetic drug metformin against apoptotic cell death in primary cortical neurons.抗糖尿病药物二甲双胍对原代皮质神经元凋亡性细胞死亡的神经保护作用。
J Mol Neurosci. 2008;34(1):77-87. doi: 10.1007/s12031-007-9002-1. Epub 2007 Nov 27.
7
Reversible blockade of electron transport during ischemia protects mitochondria and decreases myocardial injury following reperfusion.缺血期间电子传递的可逆性阻断可保护线粒体并减少再灌注后的心肌损伤。
J Pharmacol Exp Ther. 2006 Dec;319(3):1405-12. doi: 10.1124/jpet.106.110262. Epub 2006 Sep 21.
8
Modulation of electron transport protects cardiac mitochondria and decreases myocardial injury during ischemia and reperfusion.电子传递的调节可保护心脏线粒体并减少缺血再灌注期间的心肌损伤。
Am J Physiol Cell Physiol. 2007 Jan;292(1):C137-47. doi: 10.1152/ajpcell.00270.2006. Epub 2006 Sep 13.
9
Downregulation of apoptosis-inducing factor in harlequin mutant mice sensitizes the myocardium to oxidative stress-related cell death and pressure overload-induced decompensation.丑角突变小鼠中凋亡诱导因子的下调使心肌对氧化应激相关的细胞死亡和压力超负荷诱导的失代偿敏感。
Circ Res. 2005 Jun 24;96(12):e92-e101. doi: 10.1161/01.RES.0000172081.30327.28. Epub 2005 Jun 2.
10
AIF deficiency compromises oxidative phosphorylation.凋亡诱导因子缺乏会损害氧化磷酸化。
EMBO J. 2004 Nov 24;23(23):4679-89. doi: 10.1038/sj.emboj.7600461. Epub 2004 Nov 4.