线粒体医学：疾病中线粒体的药物靶向治疗
Mitochondrial medicine: pharmacological targeting of mitochondria in disease.
作者信息
Armstrong J S
机构信息
Department of Biochemistry, Faculty of Medicine, National University of Singapore, 8 Medical Drive, Singapore 117597, Singapore.
出版信息
Br J Pharmacol. 2007 Aug;151(8):1154-65. doi: 10.1038/sj.bjp.0707288. Epub 2007 May 21.
Abstract
Mitochondria play a central role in cell life and death and are known to be important in a wide range of diseases including the cancer, diabetes, cardiovascular disease, and the age-related neurodegenerative diseases. The unique structural and functional characteristics of mitochondria enable the selective targeting of drugs designed to modulate the function of this organelle for therapeutic gain. This review discusses mitochondrial drug targeting strategies and a variety of novel mitochondrial drug targets including the electron transport chain, mitochondrial permeability transition, Bcl-2 family proteins and mitochondrial DNA. Mitochondrial drug-targeting strategies will open up avenues for manipulating mitochondrial functions and allow for selective protection or eradication of cells for therapeutic gain in a variety of diseases.
摘要
线粒体在细胞生死过程中起着核心作用，并且已知在包括癌症、糖尿病、心血管疾病以及与年龄相关的神经退行性疾病在内的多种疾病中都很重要。线粒体独特的结构和功能特性使得能够选择性地靶向设计用于调节该细胞器功能以获得治疗益处的药物。本综述讨论了线粒体药物靶向策略以及多种新型线粒体药物靶点，包括电子传递链、线粒体通透性转换、Bcl-2家族蛋白和线粒体DNA。线粒体药物靶向策略将为操纵线粒体功能开辟途径，并允许在多种疾病中选择性地保护或消除细胞以获得治疗益处。
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