Yakan Savaş, Sarı Erdem, Erkan Nazif, Yıldırım Mehmet, Vardar Enver, Coşkun Ali, Çetin Durmuş Ali, Eliyatkın Nükhet
Department of General Surgery, İzmir Bozyaka Training and Research Hospital, İzmir, Turkey.
Department of Pathology, İzmir Bozyaka Training and Research Hospital, İzmir, Turkey.
J Breast Health. 2014 Jul 1;10(3):161-165. doi: 10.5152/tjbh.2014.2197. eCollection 2014 Jul.
Carcinosarcomas of the breast are rare and aggressive breast tumors. The optimal treatment strategies and the classification of these difficult to diagnose tumors are not clear in the literature due to their very low incidence. In this study, we aimed to evaluate patients who were operated on for breast carcinosarcoma and discuss the current literature.
Ten patients who were treated with a diagnosis of breast carcinosarcoma between January 2000 - March 2013 at the Izmir Bozyaka Teaching and Training Hospital General Surgery Clinics were retrospectively analyzed.
The mean age of the patients was 59.7 (±13.4) years. Eight patients underwent modified radical mastectomy, one patient lumpectomy and one patient breast conserving surgery + sentinel lymph node biopsy procedures. The TNM stage of patients were identified as stage 1 in 2 patients, stage 2 in 6 patients, and stage 3 in 2 patients. 60-month disease-free survival rate was 52.5% (±18.6). The overall survival rate was 53.3% (±20.5). Four patients died during follow-up.
It is reported that the prognosis of carcinosarcomas are as poor as triple negative epithelial tumors. In contrast to the literature, in our study the disease-free and overall survival rates according to stage were not different from epithelial tumors. In this regard, prospective studies including more patients are required.
乳腺肉瘤样癌是罕见且侵袭性强的乳腺肿瘤。由于其发病率极低，文献中对于这些难以诊断的肿瘤的最佳治疗策略及分类尚不清楚。在本研究中，我们旨在评估接受乳腺肉瘤样癌手术的患者并讨论当前文献。
回顾性分析了2000年1月至2013年3月在伊兹密尔博兹亚卡教学与培训医院普通外科门诊被诊断为乳腺肉瘤样癌并接受治疗的10例患者。
患者的平均年龄为59.7（±13.4）岁。8例患者接受了改良根治性乳房切除术，1例患者接受了肿块切除术，1例患者接受了保乳手术+前哨淋巴结活检手术。患者的TNM分期为1期2例，2期6例，3期2例。60个月无病生存率为52.5%（±18.6）。总生存率为53.3%（±20.5）。4例患者在随访期间死亡。
据报道，肉瘤样癌的预后与三阴性上皮性肿瘤一样差。与文献不同的是，在我们的研究中，根据分期的无病生存率和总生存率与上皮性肿瘤并无差异。在这方面，需要开展纳入更多患者的前瞻性研究。
