Akan Arzu, Şimsek Şerife
Clinic of General Srugery, Okmeydanı Training and Research Hospital, İstanbul, Turkey.
Clinic of Breast Surgery, EMSEY Hospital, İstanbul, Turkey.
J Breast Health. 2014 Oct 1;10(4):190-196. doi: 10.5152/tjbh.2014.2117. eCollection 2014 Oct.
Intraoperative radiation therapy in breast cancer (IORT) delivers a concentrated dose of radiation therapy to a tumor bed during surgery. IORT offers some of the following advantages with typically fewer complications like; maximum effect, sparing healthy tissues and organs, to help the patients finish treatment and get back to their normal activities. The goal of IORT is to improve local tumor control and survival rates for patients with breast cancer. IORT can both be performed with electron beams (ELIOT) and X-rays. Two main randomised trials testing intraoperative partial breast radiotherapy are TARGIT trial and the ELIOT (intraoperative radiotherapy with electrons) trial, but the techniques are fundamentally different. Whereas TARGIT delivers radiation from within the undisturbed tumour bed, for ELIOT, the mammary gland is mobilised, a prepectoral lead shield is inserted, the edges of the tumour bed are apposed, and radiation is delivered from without.
乳腺癌术中放射治疗（IORT）在手术期间向肿瘤床提供集中剂量的放射治疗。IORT具有以下一些优点，通常并发症较少，如效果最大化、 sparing healthy tissues and organs（此处英文有误，推测应为“ sparing healthy tissues and organs”，意为“保护健康组织和器官”），帮助患者完成治疗并恢复正常活动。IORT的目标是提高乳腺癌患者的局部肿瘤控制率和生存率。IORT既可以用电子束（ELIOT）进行，也可以用X射线进行。两项主要的测试术中部分乳腺放射治疗的随机试验是TARGIT试验和ELIOT（电子术中放射治疗）试验，但这两种技术有根本区别。TARGIT是在未受干扰的肿瘤床内进行放射治疗，而对于ELIOT，乳腺被移动，插入一个胸肌前铅屏蔽，肿瘤床边缘对合，然后从外部进行放射治疗。
