Kara F Gülşen, Haydaroğlu Ayfer, Eren Hakan, Kitapçıoğlu Gül
Department of Radiation Oncology, Ege University Faculty of Medicine, İzmir, Turkey.
Department of Biostatistics and Health Informatics, Ege University Faculty of Medicine, İzmir, Turkey.
J Breast Health. 2014 Apr 1;10(2):83-87. doi: 10.5152/tjbh.2014.1772. eCollection 2014 Apr.
This study aimed to minimize the radiation dose to organs other than the target tissue during adjuvant therapy applied for breast cancer, by using different planning methods.
30 women with T1-2 N1-3 M0 breast cancer were included in the study. Planning was performed using four different methods to the supraclavicular area, internal, and external tangential fields. All planning was done in a virtual environment by and the requested data was obtained. All patients were treated by the 1st method. Method 1: Different isocenter, complete supraclavicular area, breast half beam. Method 2: Different isocenter, half supraclavicular area, breast half beam. Method 3: Single isocenter, half supraclavicular area, breast half beam. Method 4: Different isocenter, supraclavicular area full beam, breast full beam.
Evaluation of PTV values showed a statistically significant reduction in D-max, 110% and 115% values by method III. Lower doses in other parameters were not statistically significant.
Based on these results, the application of single isocenter, 3D radiotherapy in breast cancer provides significant advantages especially in PTV and pulmonary dosages.
本研究旨在通过使用不同的计划方法，在乳腺癌辅助治疗期间将靶组织以外器官的辐射剂量降至最低。
30例T1-2 N1-3 M0期乳腺癌女性纳入本研究。对锁骨上区、内切线野和外切线野采用四种不同方法进行计划。所有计划均在虚拟环境中完成并获取所需数据。所有患者均采用第一种方法进行治疗。方法1：不同等中心，完整锁骨上区，乳腺半束。方法2：不同等中心，半锁骨上区，乳腺半束。方法3：单一等中心，半锁骨上区，乳腺半束。方法4：不同等中心，锁骨上区全束，乳腺全束。
PTV值评估显示，方法III的D-max、110%和115%值有统计学意义的降低。其他参数的较低剂量无统计学意义。
基于这些结果，单一等中心的三维放射治疗在乳腺癌中的应用尤其在PTV和肺部剂量方面具有显著优势。
