Zimmerman Asha, Grand David, Charpentier Kevin P
Department of Surgery.
Department of Radiology, Rhode Island Hospital, Brown University, Providence, RI, USA.
J Hepatocell Carcinoma. 2017 Mar 13;4:49-58. doi: 10.2147/JHC.S129063. eCollection 2017.
Irreversible electroporation (IRE) is a novel form of tissue ablation that uses high-current electrical pulses to induce pore formation of the cell lipid bilayer, leading to cell death. The safety of IRE for ablation of hepatocellular carcinoma (HCC) has been established. Outcome data for ablation of HCC by IRE are limited, but early results are encouraging and suggest equivalency to the outcomes obtained for thermal ablation for appropriately selected, small (<3 cm) tumors. Long-term oncologic efficacy and histopathologic response data have not been published, and therefore, application of IRE for the treatment of HCC should still be viewed with caution.
不可逆电穿孔（IRE）是一种新型的组织消融形式，它利用高电流电脉冲诱导细胞脂质双分子层形成孔隙，从而导致细胞死亡。IRE用于肝细胞癌（HCC）消融的安全性已得到证实。IRE消融HCC的结果数据有限，但早期结果令人鼓舞，表明对于适当选择的小（<3 cm）肿瘤，其结果与热消融相当。长期肿瘤学疗效和组织病理学反应数据尚未公布，因此，IRE在HCC治疗中的应用仍应谨慎看待。
