Moghaddam Omid Moradi, Lahiji Mohammad Niakan, Moghaddas Azadeh, Farasatinasab Maryam, Nasiripour Somayyeh
Critical Care Department, Rasool-e-Akram Hospital, Iran University of Medical Sciences, Tehran, Iran.
Department of Clinical Pharmacy, Isfahan University of Medical Sciences, Isfahan, Iran.
J Res Pharm Pract. 2017 Jan-Mar;6(1):52-55. doi: 10.4103/2279-042X.200991.
Selenium depletion has been reported in critical illness correlates with an increase in mortality and morbidity. In this study, we aimed to access the selenium plasma levels of septic patients early at the Intensive Care Unit (ICU) admission in order to compare with reference range.
We conducted a cross-sectional study in a university affiliated hospital aiming to assess the early plasma level of selenium in ICU admitted patients. eighty patients diagnoses with sepsis were included and considered for characteristic evaluation, monitoring criteria assessment and also blood sampling. All blood sampling was performed during 48 hours of the ICU admission in order to determined the plasma Selenium level by atomic absorption method.
The mean plasma levels of selenium in male and female was 98.14 ± 23.52 and 78.1 ± 24.46 μ/L, respectively. Although selenium plasma levels was higher in the ICU male patients significantly, both had near normal range (80 μ/L).
In this study we found that in early admitted Iranian ICU patients in Tehran, selenium deficiency has not routinely seen but probably will happen during ICU hospitalization.
据报道，危重病患者存在硒缺乏，这与死亡率和发病率的增加相关。在本研究中，我们旨在在重症监护病房（ICU）入院时尽早检测脓毒症患者的血浆硒水平，以便与参考范围进行比较。
我们在一家大学附属医院进行了一项横断面研究，旨在评估入住ICU患者的早期血浆硒水平。纳入80例诊断为脓毒症的患者，并对其进行特征评估、监测标准评估以及血液采样。所有血液采样均在入住ICU的48小时内进行，以便通过原子吸收法测定血浆硒水平。
男性和女性的血浆硒平均水平分别为98.14±23.52和78.1±24.46μ/L。虽然ICU男性患者的血浆硒水平显著更高，但两者均接近正常范围（80μ/L）。
在本研究中，我们发现，在德黑兰早期入院的伊朗ICU患者中，未经常见到硒缺乏，但在ICU住院期间可能会发生。
