Lee Chan Ho, Park Young Joo, Ku Ja Yoon, Ha Hong Koo
Department of Urology, Pusan National University Hospital, Pusan National University School of Medicine, Busan, Korea.
Biomedical Research Institute, Pusan National University Hospital, Busan, Korea.
Int J Urol. 2017 Jun;24(6):433-439. doi: 10.1111/iju.13338. Epub 2017 Mar 22.
To evaluate the clinical application of computed tomography-based measurement of renal cortical volume and split renal volume as a single tool to assess the anatomy and renal function in patients with renal tumors before and after partial nephrectomy, and to compare the findings with technetium-99m dimercaptosuccinic acid renal scan.
The data of 51 patients with a unilateral renal tumor managed by partial nephrectomy were retrospectively analyzed. The renal cortical volume of tumor-bearing and contralateral kidneys was measured using ImageJ software. Split estimated glomerular filtration rate and split renal volume calculated using this renal cortical volume were compared with the split renal function measured with technetium-99m dimercaptosuccinic acid renal scan.
A strong correlation between split renal function and split renal volume of the tumor-bearing kidney was observed before and after surgery (r = 0.89, P < 0.001 and r = 0.94, P < 0.001). The preoperative and postoperative split estimated glomerular filtration rate of the operated kidney showed a moderate correlation with split renal function (r = 0.39, P = 0.004 and r = 0.49, P < 0.001). The correlation between reductions in split renal function and split renal volume of the operated kidney (r = 0.87, P < 0.001) was stronger than that between split renal function and percent reduction in split estimated glomerular filtration rate (r = 0.64, P < 0.001).
The split renal volume calculated using computed tomography-based renal volumetry had a strong correlation with the split renal function measured using technetium-99m dimercaptosuccinic acid renal scan. Computed tomography-based split renal volume measurement before and after partial nephrectomy can be used as a single modality for anatomical and functional assessment of the tumor-bearing kidney.
评估基于计算机断层扫描测量肾皮质体积和分侧肾体积作为一种单一工具，用于评估肾肿瘤患者在部分肾切除术前和术后的肾脏解剖结构及肾功能，并将结果与锝-99m二巯基丁二酸肾扫描结果进行比较。
回顾性分析51例接受部分肾切除术治疗的单侧肾肿瘤患者的数据。使用ImageJ软件测量患侧和对侧肾脏的肾皮质体积。将根据该肾皮质体积计算出的分侧估计肾小球滤过率和分侧肾体积与锝-99m二巯基丁二酸肾扫描测量的分侧肾功能进行比较。
术前和术后均观察到患侧肾脏的分侧肾功能与分侧肾体积之间存在强相关性（r = 0.89，P < 0.001；r = 0.94，P < 0.001）。手术侧肾脏术前和术后的分侧估计肾小球滤过率与分侧肾功能呈中度相关（r = 0.39，P = 0.004；r = 0.49，P < 0.001）。手术侧肾脏分侧肾功能降低与分侧肾体积降低之间的相关性（r = 0.87，P < 0.001）强于分侧肾功能与分侧估计肾小球滤过率降低百分比之间的相关性（r = 0.64，P < 0.001）。
基于计算机断层扫描的肾体积测量法计算出的分侧肾体积与锝-99m二巯基丁二酸肾扫描测量的分侧肾功能密切相关。部分肾切除术前和术后基于计算机断层扫描的分侧肾体积测量可作为评估患侧肾脏解剖和功能的单一方法。
