甘草次酸对大鼠脂肪组织葡萄糖代谢的影响。

Effect of carbenoxolone on glucose metabolism in rat adipose tissue.

作者信息

Gomez-Capilla J A, Gutierrez C, Fernández-Fernández J M

机构信息

Departamento de Bioquimica, Facultad de Medicina, Universidad de Granada, Spain.

出版信息

Biochem Pharmacol. 1988 Apr 1;37(7):1299-301. doi: 10.1016/0006-2952(88)90786-1.

DOI:10.1016/0006-2952(88)90786-1

PMID:2833277

Abstract

Carbenoxolone significantly decreased the glucose uptake and the incorporation of glucose into triglycerides and CO2 in rat epididymal fat pads. The effect produced by insulin on these metabolic pathways was reduced when adipose tissue was incubated with insulin in the presence of carbenoxolone (10(-3) M). On the other hand the drug (10(-3) M) produced a decrease in cyclic AMP concentration in adipose tissue similar to that produced by insulin (100 ng/ml).

摘要

甘草次酸显著降低了大鼠附睾脂肪垫中葡萄糖的摄取以及葡萄糖掺入甘油三酯和二氧化碳的量。当脂肪组织在存在甘草次酸（10⁻³ M）的情况下与胰岛素一起孵育时，胰岛素对这些代谢途径产生的作用会减弱。另一方面，该药物（10⁻³ M）使脂肪组织中环磷酸腺苷（cAMP）的浓度降低，其降低程度与胰岛素（100 ng/ml）产生的相似。