甘珀酸对大鼠脂肪组织脂肪分解的影响。
Effect of carbenoxolone on lipolysis in rat adipose tissue.
作者信息
Lambert B, Godard C, Jacquemin C
出版信息
J Pharm Pharmacol. 1978 May;30(5):301-3. doi: 10.1111/j.2042-7158.1978.tb13234.x.
Abstract
Carbenoxolone slightly but significantly decreased the release of FFA from rat epididymal fat pads. The antilipolytic action of carbenoxolone was not blocked by 10(-3)M 3-isobutyl-1-methylxanthine, a potent inhibitor of phosphodiesterase. The findings suggest that carbenoxolone exerts its antilipolytic activity by acting on adenylate cyclase, thereby decreasing cyclic AMP concentrations and the activity of the hormone-sensitive lipase in adipose tissue.
摘要
甘草次酸能轻微但显著地减少大鼠附睾脂肪垫中游离脂肪酸的释放。甘草次酸的抗脂解作用不会被10⁻³M的3-异丁基-1-甲基黄嘌呤（一种有效的磷酸二酯酶抑制剂）所阻断。这些发现表明，甘草次酸通过作用于腺苷酸环化酶发挥其抗脂解活性，从而降低环磷酸腺苷浓度以及脂肪组织中激素敏感性脂肪酶的活性。
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