Carvalho Bruno R de, Barbosa Marina W Paes, Bonesi Helena, Gomes David B, Cabral Íris O, Barbosa Antônio C Paes, Silva Adelino A, Iglesias José R, Nakagawa Hitomi M
GENESIS - Center for Assistance in Human Reproduction, Brasília, DF, Brazil.
JBRA Assist Reprod. 2017 Feb 1;21(1):23-26. doi: 10.5935/1518-0557.20170007.
To evaluate if the outcomes of IVF/ICSI in frozen-thawed embryo transfer and fresh embryo transfer cycles differ in relation to cleavage and blastocyst stages.
Retrospective cohort study to compare IVF/ICSI outcomes between fresh embryo transfer and frozen-thawed embryo transfer cycles, according to the stage of embryo development. Analysis was carried out on 443 consecutive embryo transfer cycles performed between January 1st and December 31st, 2014. Women aged up to 38 and submitted to embryo transfer cycles with fresh (n = 309) or frozen-thawed (n = 134) embryos at a private center for assistance in human reproduction were considered for analysis. Results in each group were stratified according to the stage of embryo development: cleavage stage and blastocyst stage. Main outcome measures were implantation rate, clinical pregnancy rate, ongoing pregnancy rate and live birth rate per cycle.
In the fresh embryo transfer group, for cleavage stage versus blastocyst stage, respectively, implantation rates were 22% and 47% (p = 0.0005); clinical pregnancy rates were 34% and 64% (p = 0.0057); the ongoing pregnancy rates were 30% and 61% (p = 0.0046) and live birth rates were 28% and 55% (p = 0.0148). There were no significant differences in the rates between cleavage and blastocyst stages in the frozen-thawed group, neither between fresh and frozen-thawed cleavage embryo transfers nor between fresh and frozen-thawed blastocyst transfers.
Our results confirm that blastocyst transfer is better than cleavage stage in fresh embryo transfer cycles. In frozen-thawed cycles, cleavage or blastocyst stages seem to offer similar reproductive outcomes.
评估在冻融胚胎移植和新鲜胚胎移植周期中，体外受精/卵胞浆内单精子注射（IVF/ICSI）的结果在卵裂期和囊胚期方面是否存在差异。
进行回顾性队列研究，根据胚胎发育阶段比较新鲜胚胎移植和冻融胚胎移植周期的IVF/ICSI结果。对2014年1月1日至12月31日期间连续进行的443个胚胎移植周期进行分析。纳入分析的是一家私人人类生殖辅助中心中年龄在38岁及以下、接受新鲜（n = 309）或冻融（n = 134）胚胎移植周期的女性。每组结果根据胚胎发育阶段分层：卵裂期和囊胚期。主要观察指标为每个周期的着床率、临床妊娠率、持续妊娠率和活产率。
在新鲜胚胎移植组中，卵裂期与囊胚期的着床率分别为22%和47%（p = 0.0005）；临床妊娠率分别为34%和64%（p = 0.0057）；持续妊娠率分别为30%和61%（p = 0.0046），活产率分别为28%和55%（p = 0.0148）。在冻融组中，卵裂期和囊胚期之间的比率没有显著差异，新鲜和冻融卵裂期胚胎移植之间以及新鲜和冻融囊胚移植之间也没有显著差异。
我们的结果证实，在新鲜胚胎移植周期中，囊胚移植优于卵裂期。在冻融周期中，卵裂期或囊胚期似乎提供相似的生殖结局。
