Xia En-Qin, Zhu Shan-Shan, He Min-Jing, Luo Fei, Fu Cheng-Zhan, Zou Tang-Bin
Dongguan Key Laboratory of Environmental Medicine, School of Public Health, Guangdong Medical University, Dongguan 523808, China.
Mar Drugs. 2017 Mar 23;15(4):88. doi: 10.3390/md15040088.
An increasing prevalence of diabetes is known as a main risk for human health in the last future worldwide. There is limited evidence on the potential management of type 2 diabetes mellitus using bioactive peptides from marine organisms, besides from milk and beans. We summarized here recent advances in our understanding of the regulation of glucose metabolism using bioactive peptides from natural proteins, including regulation of insulin-regulated glucose metabolism, such as protection and reparation of pancreatic β-cells, enhancing glucose-stimulated insulin secretion and influencing the sensitivity of insulin and the signaling pathways, and inhibition of bioactive peptides to dipeptidyl peptidase IV, α-amylase and α-glucosidase activities. The present paper tried to understand the underlying mechanism involved and the structure characteristics of bioactive peptides responsible for its antidiabetic activities to prospect the utilization of rich marine organism proteins.
在全球范围内，糖尿病患病率的不断上升是未来人类健康的主要风险之一。除了来自牛奶和豆类的生物活性肽外，关于利用海洋生物来源的生物活性肽对2型糖尿病进行潜在管理的证据有限。我们在此总结了利用天然蛋白质来源的生物活性肽调节葡萄糖代谢方面的最新进展，包括胰岛素调节的葡萄糖代谢调节，如胰腺β细胞的保护和修复、增强葡萄糖刺激的胰岛素分泌以及影响胰岛素敏感性和信号通路，以及生物活性肽对二肽基肽酶IV、α-淀粉酶和α-葡萄糖苷酶活性的抑制作用。本文试图了解其中涉及的潜在机制以及负责其抗糖尿病活性的生物活性肽的结构特征，以期对丰富的海洋生物蛋白质加以利用。
