State Key Laboratory for Managing Biotic and Chemical Threats to the Quality and Safety of Agro-products, Ningbo University, Ningbo, Zhejiang 315211, China; Zhejiang-Malaysia Joint Research Laboratory for Agricultural Product Processing and Nutrition, College of Food Science and Engineering, Ningbo University, Ningbo 315800, China; Zhejiang Key Laboratory of Food Microbiology and Nutritional Health, Hangzhou 310018, China.
State Key Laboratory for Managing Biotic and Chemical Threats to the Quality and Safety of Agro-products, Ningbo University, Ningbo, Zhejiang 315211, China; Zhejiang-Malaysia Joint Research Laboratory for Agricultural Product Processing and Nutrition, College of Food Science and Engineering, Ningbo University, Ningbo 315800, China; Zhejiang Key Laboratory of Food Microbiology and Nutritional Health, Hangzhou 310018, China.
Int J Biol Macromol. 2024 Nov;279(Pt 1):134993. doi: 10.1016/j.ijbiomac.2024.134993. Epub 2024 Aug 23.
Type 2 diabetes mellitus (T2DM), a disease that threatens public health worldwide and can cause a series of irreversible complications, has been a major concern. Although the treatment based on hypoglycemic drugs is effective, its side effects should not be ignored, which has led to an urgent need for developing new hypoglycemic drugs. Bioactive peptides with antidiabetic effects obtained from food proteins have become a research hotspot as they are safer and with higher specificity than traditional hypoglycemic drugs. Here, we reviewed antidiabetic peptides that have the ability to inhibit key enzymes (α-glucosidase, α-amylase, and DPP-IV) in T2DM, the hypoglycemic mechanisms and structure-activity relationships were summarized, some antidiabetic peptides that improve insulin resistance and reverse gut microbiota and their metabolites were overviewed, the bitterness of antidiabetic peptides was predicted in silico, proposed solutions to the current challenges encountered in the development of antidiabetic peptide drugs, and provided an outlook on the future focus of commercial production. It provides a reference for the application of food-derived antidiabetic peptides.
2 型糖尿病（T2DM）是一种威胁全球公众健康的疾病，可引起一系列不可逆的并发症，一直备受关注。尽管基于降血糖药物的治疗方法有效，但不应忽视其副作用，这导致人们迫切需要开发新的降血糖药物。从食物蛋白中获得的具有降血糖作用的生物活性肽由于比传统降血糖药物更安全、特异性更高，已成为研究热点。在这里，我们综述了具有抑制 2 型糖尿病关键酶（α-葡萄糖苷酶、α-淀粉酶和 DPP-IV）能力的抗糖尿病肽，总结了其降血糖机制和构效关系，综述了一些改善胰岛素抵抗和逆转肠道微生物群及其代谢物的抗糖尿病肽，对抗糖尿病肽的苦味进行了计算机预测，提出了解决抗糖尿病肽药物开发中遇到的当前挑战的解决方案，并对未来的商业生产重点进行了展望。为食品来源的抗糖尿病肽的应用提供了参考。
