Institut Necker Enfants Malades, 75993 Paris, France.
Université Paris Descartes, 75993, Paris, France.
Pathog Dis. 2017 Apr 1;75(3). doi: 10.1093/femspd/ftx027.
Purpura fulminans (PF) is a dreadful and frequent complication of Neisseria meningitidis invasive infection, and is associated with a high mortality rate. This syndrome begins with dermal microvessels thrombosis that rapidly lead to hemorrhagic skin necrosis. In this review, we discuss the prothrombotic events occurring during meningococcal infection. Moreover, recent data from an experimental mouse model have highlighted the critical role of the meningococcus adhesion to the endothelium in the development of PF lesions, thus opening new therapeutic perspectives.
暴发性紫癜（PF）是脑膜炎奈瑟菌侵袭性感染的一种严重且常见的并发症，与高死亡率相关。该综合征始于皮肤微血管血栓形成，迅速导致皮肤出血性坏死。在这篇综述中，我们讨论了脑膜炎奈瑟菌感染过程中的促血栓形成事件。此外，来自实验性小鼠模型的最新数据强调了脑膜炎奈瑟菌黏附在内皮细胞上在 PF 病变发展中的关键作用，从而为治疗提供了新的视角。
