Ságová Ivana, Stančík Matej, Kentoš Peter, Pavai Dušan, Kantárová Daniela, Vaňuga Anton, Vaňuga Peter
Vnitr Lek. 2017 Winter;63(2):139-144.
Parathyroid cancer is a rare endocrine malignancy, representing less than 1 % of all cases of primary hyperparathyroidism. The exact etiology of the disease remains unknown. Known risk factors include neck irradiation, end stage renal failure, genetic factors, particularly the the HPRT2/CDCT73 gene mutation. The clinical picture is often indolent, yet progressive with a trend of local invasion and metastasis formation in advanced disease. The clinical picture includes symptoms of severe and resistant hypercalcemia, requiring intensive therapy often with the need of dialysis. Radical surgery is the mainstay of the parathyroid cancer treatment. Chemotherapy and radiotherapy are generally ineffective. An early and correct diagnosis of parathyroid carcinoma significantly influences both morbidity and mortality.Key words: diagnosis - hyperparathyroidism - parathyroid cancer - treatment.
甲状旁腺癌是一种罕见的内分泌恶性肿瘤，占原发性甲状旁腺功能亢进所有病例的不到1%。该病的确切病因尚不清楚。已知的风险因素包括颈部放疗、终末期肾衰竭、遗传因素，特别是HPRT2/CDCT73基因突变。临床表现通常较为隐匿，但呈进行性发展，晚期疾病有局部侵袭和转移形成的趋势。临床表现包括严重且难治性高钙血症的症状，常需强化治疗，且往往需要透析。根治性手术是甲状旁腺癌治疗的主要方法。化疗和放疗一般无效。甲状旁腺癌的早期正确诊断对发病率和死亡率均有显著影响。关键词：诊断 - 甲状旁腺功能亢进 - 甲状旁腺癌 - 治疗
