Kim Byung Seup, Ryu Han Suk, Kang Kyung Ho, Park Sung Jun
Department of Surgery, Chung-Ang University, College of Medicine, Chung-Ang University Hospital, Seoul, South Korea.
Department of Pathology, Chung-Ang University, College of Medicine, Chung-Ang University Hospital, Seoul, South Korea.
Asian J Surg. 2016 Oct;39(4):255-9. doi: 10.1016/j.asjsur.2013.01.007. Epub 2013 Mar 26.
Parathyroid carcinoma is a rare disease of unknown etiology. This study presents a case of parathyroid carcinoma in a patient with tertiary hyperparathyroidism. Despite a successful kidney transplantation, the intact parathyroid hormone (iPTH) level of the patient was elevated consistently and could not be controlled by medical therapy. Due to the development of tertiary hyperparathyroidism with bone pain and osteoporosis, subtotal parathyroidectomy was performed 4 months after the kidney transplantation. Histological evaluation revealed that one of four parathyroid lesions was a parathyroid carcinoma, while the others were diffuse hyperplasia. Postoperative laboratory studies indicated a decreased level of iPTH. A positron emission tomography-computed tomography performed 6 months after the operation revealed no evidence of local recurrence or distant metastasis.
甲状旁腺癌是一种病因不明的罕见疾病。本研究报告了一例患有三发性甲状旁腺功能亢进症的甲状旁腺癌患者。尽管成功进行了肾脏移植，但患者的完整甲状旁腺激素（iPTH）水平持续升高，且药物治疗无法控制。由于三发性甲状旁腺功能亢进症的发展导致骨痛和骨质疏松，在肾脏移植后4个月进行了甲状旁腺次全切除术。组织学评估显示，四个甲状旁腺病变中有一个是甲状旁腺癌，其他为弥漫性增生。术后实验室检查表明iPTH水平降低。术后6个月进行的正电子发射断层扫描-计算机断层扫描显示没有局部复发或远处转移的迹象。
