TIR 轴突分离：出乎意料的 NADase 控制轴突变性。
TIR Axons Apart: Unpredicted NADase Controls Axonal Degeneration.
机构信息
Department of Biomolecular Sciences, Weizmann Institute of Science, Rehovot 76100, Israel.
Department of Biomolecular Sciences, Weizmann Institute of Science, Rehovot 76100, Israel.
出版信息
Neuron. 2017 Mar 22;93(6):1239-1241. doi: 10.1016/j.neuron.2017.03.005.
PMID:28334598
Abstract
SARM1 is a key regulator of axonal degeneration. However, SARM1 mechanism of action is not clear. In this issue of Neuron, Essuman et al. (2017) reveal an intrinsic NADase activity in the SARM1-TIR domain that is required for axonal degeneration.
摘要
SARM1 是轴突退化的关键调节因子。然而，SARM1 的作用机制尚不清楚。在本期《神经元》杂志上，Essuman 等人（2017）揭示了 SARM1-TIR 结构域中的固有 NADase 活性，该活性对于轴突退化是必需的。
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