Ting Wei-Jen, Huang Chih-Yang, Jiang Chong-He, Lin Yueh-Min, Chung Li-Chin, Shen Chia-Yao, Pai Peiying, Lin Kuan-Ho, Viswanadha Vijaya Padma, Liao Shih-Chieh
The Sixth Affiliated Hospital of Guangzhou Medical University, Qingyuan People's Hospital, B24 Yinquan South Road, Qingyuan 511518, China.
Graduate Institute of Basic Medical Science, China Medical University, 91 Hsueh-Shih Road, Taichung 40402, Taiwan.
Int J Mol Sci. 2017 Mar 14;18(3):629. doi: 10.3390/ijms18030629.
Estrogen receptor α (ERα) and estrogen receptor β (ERβ) play important roles in cardiovascular disease (CVD) prevention. Recently, these estrogen receptors were reconsidered as an important treatment target of obesity leading to CVD. In this study, 17β-estradiol (17β-E) replacement therapy applied to high-fat diet-induced obese C57B male mice and ovariectomized (OVX) rats were evaluated, and the protective effects against high-fat diet-induced obesity were assessed in C57B mouse hearts. The results showed that 17β-E treatment activated both ERα and ERβ, and ERβ levels increased in a dose-dependent manner in high-fat diet C57B mouse cardiomyocytes following 17β-E treatment. Notably, an almost 16% reduction in body weight was observed in the 17β-E-treated (12 μg/kg/day for 60 days) high-fat diet-induced obese C57B male mice. These results suggested that 17β-E supplements may reduce CVD risk due to obesity.
雌激素受体α（ERα）和雌激素受体β（ERβ）在心血管疾病（CVD）预防中发挥着重要作用。最近，这些雌激素受体被重新视为导致CVD的肥胖症的重要治疗靶点。在本研究中，评估了应用于高脂饮食诱导的肥胖C57B雄性小鼠和去卵巢（OVX）大鼠的17β-雌二醇（17β-E）替代疗法，并在C57B小鼠心脏中评估了对高脂饮食诱导的肥胖症的保护作用。结果表明，17β-E治疗激活了ERα和ERβ，并且在17β-E治疗后的高脂饮食C57B小鼠心肌细胞中，ERβ水平呈剂量依赖性增加。值得注意的是，在接受17β-E治疗（12μg/kg/天，持续60天）的高脂饮食诱导的肥胖C57B雄性小鼠中，体重减轻了近16%。这些结果表明，17β-E补充剂可能降低肥胖导致的CVD风险。
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