Davidson Ben, Micci Francesca
a Department of Pathology , Norwegian Radium Hospital, Oslo University Hospital , Oslo , Norway.
b Institute of Clinical Medicine , University of Oslo , Oslo , Norway.
Expert Rev Mol Diagn. 2017 May;17(5):515-522. doi: 10.1080/14737159.2017.1311790. Epub 2017 Apr 3.
Uterine sarcomas are rare cancers, of which the most common entities are leiomyosarcoma and endometrial stromal sarcoma. These two tumors may have overlapping clinical presentation, morphology and immunohistochemical profile, but are increasingly recognized to be two molecularly distinct entities. Endometrial stromal sarcomas are further currently divided into a low-grade and high-grade group based on molecular characteristics. Area covered: This review discusses recent data which shed light on the molecular profile of these two cancers and may aid in understanding their evolution and progression, in the aim of improving their diagnosis and management. Search was through PubMed, with focus on studies published in the last 5 years. Expert commentary: The literature presented and discussed documents rapidly expanding knowledge of the genetic characteristics of leiomyosarcoma and endometrial stromal sarcoma, with an array of molecules and pathways implicated in the biology of these cancers. Several of these molecules are potential therapeutic targets. Assessment of their predictive and prognostic role awaits larger studies.
子宫肉瘤是罕见的癌症，其中最常见的类型是平滑肌肉瘤和子宫内膜间质肉瘤。这两种肿瘤可能具有重叠的临床表现、形态学和免疫组化特征，但越来越被认为是两种分子特征不同的实体。目前，子宫内膜间质肉瘤根据分子特征进一步分为低级别和高级别组。涵盖领域：本综述讨论了最近的数据，这些数据揭示了这两种癌症的分子特征，可能有助于理解它们的演变和进展，目的是改善它们的诊断和管理。通过PubMed进行检索，重点关注过去5年发表的研究。专家评论：所呈现和讨论的文献记录了平滑肌肉瘤和子宫内膜间质肉瘤遗传特征方面迅速扩展的知识，涉及一系列与这些癌症生物学相关的分子和途径。其中一些分子是潜在的治疗靶点。对它们的预测和预后作用的评估有待更大规模的研究。
