Department of Clinical Therapeutics, Oncology Unit, Alexandra Hospital, Vasilisis Sofias, 80, Athens, Greece.
Obstetrics and Gynecology Department, Alexandra Hospital, Vasilisis Sofias, 80, Athens, Greece.
BMC Cancer. 2018 Dec 13;18(1):1247. doi: 10.1186/s12885-018-5156-1.
Uterine sarcomas consist a heterogeneous group of mesenchymal gynecological malignancies with unclear therapeutic recommendations and unspecific but poor prognosis, since they usually metastasize and tend to recur very often, even in early stages.
We retrospectively analyzed all female patients with uterine sarcomas treated in our institution over the last 17 years. Clinico-pathological data, treatments and outcomes were recorded. Kaplan-Meier curves were plotted and time-to-event analyses were estimated using Cox regression.
Data were retrieved from 61 women with a median age of 53 (range: 27-78) years, at diagnosis. Fifty-one patients were diagnosed with leiomyosarcoma (LMS), 3 with high grade endometrial stromal sarcoma (ESS), 5 with undifferentiated uterine sarcoma (UUS), 1 with Ewing sarcoma (ES) and 1 with Rhabdomyosarcoma (RS). 24 cases had stage I, 7 stage II, 14 stage III and 16 stage IV disease. Median disease-free survival (DFS) in adjuvant approach was 18.83 months, and median overall survival (OS) 31.07 months. High mitotic count (> 15 mitoses) was significantly associated with worse OS (P < 0.001) and worse DFS (P = 0.028).
Mitotic count appears to be independent prognostic factor while further insights are needed to improve adjuvant and palliative treatment of uterine sarcomas.
子宫肉瘤是一组异质性的间充质妇科恶性肿瘤，治疗建议不明确，预后通常较差，因为它们通常会转移，并且经常复发，即使在早期也是如此。
我们回顾性分析了过去 17 年在我们机构治疗的所有女性子宫肉瘤患者。记录了临床病理数据、治疗方法和结果。绘制 Kaplan-Meier 曲线，并使用 Cox 回归估计时间事件分析。
数据来自 61 名中位年龄为 53 岁（范围：27-78 岁）的女性患者，诊断时。51 例患者被诊断为平滑肌肉瘤（LMS），3 例为高级别子宫内膜间质肉瘤（ESS），5 例为未分化子宫肉瘤（UUS），1 例为尤文肉瘤（ES）和 1 例横纹肌肉瘤（RS）。24 例为 I 期，7 例为 II 期，14 例为 III 期，16 例为 IV 期。辅助治疗的中位无病生存（DFS）为 18.83 个月，中位总生存（OS）为 31.07 个月。高有丝分裂计数（>15 个有丝分裂）与 OS（P<0.001）和 DFS（P=0.028）较差显著相关。
有丝分裂计数似乎是一个独立的预后因素，需要进一步深入了解以改善子宫肉瘤的辅助和姑息治疗。
