骨外骨肉瘤中的肿瘤溶解综合征：一例报告并文献复习
Tumor lysis syndrome in an extraskeletal osteosarcoma: a case report and review of the literature.
作者信息
Catania Vito Emanuele, Vecchio Michele, Malaguarnera Michele, Madeddu Roberto, Malaguarnera Giulia, Latteri Saverio
机构信息
Department of Medical-Surgical Sciences, and Advanced Technologies "G. F. Ingrassia", University of Catania, via Santa Sofia 86, 95123, Catania, Italy.
UOC Centre of Physical Medicine and Rehabilitation, AOU "O.V.E-Policlinico", Catania, Italy.
出版信息
J Med Case Rep. 2017 Mar 24;11(1):79. doi: 10.1186/s13256-017-1241-3.
BACKGROUND
This case report describes a spontaneous tumor lysis syndrome due to a rare solid tumor.
CASE PRESENTATION
A 65-year-old white woman had tumor lysis syndrome, which represent a dangerous oncological emergency. This syndrome occurs usually with a hematological tumor, but in this case our patient had a solid tumor, which was a rare extraskeletal osteosarcoma, localized in her pelvic region. She also had lung metastases and bilateral hydronephrosis. After spontaneous tumor lysis syndrome, she had acute renal insufficiency, which was treated with hemodialysis and successively with rasburicase, Kayexalate (sodium polystyrene sulfonate), and febuxostat.
CONCLUSION
Tumor lysis syndrome represents an oncological emergency, which must be suspected and treated as soon as possible.
背景
本病例报告描述了一例由罕见实体瘤引起的自发性肿瘤溶解综合征。
病例介绍
一名65岁的白人女性患有肿瘤溶解综合征，这是一种危险的肿瘤急症。该综合征通常发生于血液系统肿瘤，但在本病例中，我们的患者患有实体瘤，为罕见的骨外骨肉瘤，位于盆腔区域。她还伴有肺转移和双侧肾积水。自发性肿瘤溶解综合征发生后，她出现了急性肾功能不全，接受了血液透析治疗，随后使用了拉布立酶、聚苯乙烯磺酸钠和非布司他进行治疗。
结论
肿瘤溶解综合征是一种肿瘤急症，必须尽早怀疑并进行治疗。
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