Department of Oncology.
Int J Gen Med. 2009 Jul 30;2:1-4.
Tumor lysis syndrome (TLS), a result of rapid cell lysis following tumor therapy, is a well recognized complication during the treatment of rapidly growing tumors. TLS rarely occurs in solid tumors. We present a case report of TLS in a patient with primary retroperitoneal soft tissue sarcoma. TLS occurred in the patient after four days' combinational chemotherapy with cisplatin, adriamycin, and dacarbazine. These drugs were selected on the basis of an ex vivo ATP-based tumor sensitivity assay. TLS was properly controlled in the patient with concomitant remission of the sarcoma. Therefore, precautions should be taken to avoid this potentially fatal complication during treatment of solid tumors, especially with tumors highly sensitive to drugs.
肿瘤溶解综合征（TLS）是肿瘤治疗后细胞快速溶解的结果，是快速生长肿瘤治疗过程中一种公认的并发症。TLS 在实体瘤中很少见。我们报告了一例原发性腹膜后软组织肉瘤患者的 TLS 病例。该患者在顺铂、阿霉素和达卡巴嗪联合化疗 4 天后发生 TLS。这些药物是根据体外基于 ATP 的肿瘤敏感性测定选择的。肉瘤缓解的同时，TLS 也得到了适当的控制。因此，在治疗实体瘤时，特别是对药物高度敏感的肿瘤，应采取预防措施避免这种潜在致命的并发症。
