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积分质量监测仪透射探测器对高能光子束的影响:一项多中心研究。

Influence of the Integral Quality Monitor transmission detector on high energy photon beams: A multi-centre study.

作者信息

Casar Bozidar, Pasler Marlies, Wegener Sonja, Hoffman David, Talamonti Cinzia, Qian Jianguo, Mendez Ignasi, Brojan Denis, Perrin Bruce, Kusters Martijn, Canters Richard, Pallotta Stefania, Peterlin Primoz

机构信息

Department of Radiation Physics, Institute of Oncology, Ljubljana, Slovenia.

Lake Constance Radiation Oncology Centre, Singen & Friedrichshafen, Germany.

出版信息

Z Med Phys. 2017 Sep;27(3):232-242. doi: 10.1016/j.zemedi.2016.10.001. Epub 2017 Mar 21.

Abstract

PURPOSE

The influence of the Integral Quality Monitor (IQM) transmission detector on photon beam properties was evaluated in a preclinical phase, using data from nine participating centres: (i) the change of beam quality (beam hardening), (ii) the influence on surface dose, and (iii) the attenuation of the IQM detector.

METHODS

For 6 different nominal photon energies (4 standard, 2 FFF) and square field sizes from 1×1cm to 20×20cm, the effect of IQM on beam quality was assessed from the PDD values obtained from the percentage dose depth (PDD) curves, measured with and without IQM in the beam path. The change in surface dose with/without IQM was assessed for all available energies and field sizes from 4×4cm to 20×20cm. The transmission factor was calculated by means of measured absorbed dose at 10cm depth for all available energies and field sizes.

RESULTS

(i) A small (0.11-0.53%) yet statistically significant beam hardening effect was observed, depending on photon beam energy. (ii) The increase in surface dose correlated with field size (p<0.01) for all photon energies except for 18MV. The change in surface dose was smaller than 3.3% in all cases except for the 20×20cm field and 10MV FFF beam, where it reached 8.1%. (iii) For standard beams, transmission of the IQM showed a weak dependence on the field size, and a pronounced dependence on the beam energy (0.9412 for 6MV to 0.9578 for 18MV and 0.9440 for 6MV FFF; 0.9533 for 10MV FFF).

CONCLUSIONS

The effects of the IQM detector on photon beam properties were found to be small yet statistically significant. The magnitudes of changes which were found justify treating IQM either as tray factors within the treatment planning system (TPS) for a particular energy or alternatively as modified outputs for specific beam energy of linear accelerators, which eases the introduction of the IQM into clinical practice.

摘要

目的

在临床前阶段,利用来自九个参与中心的数据,评估积分质量监测器(IQM)传输探测器对光子束特性的影响:(i)束流质量的变化(束硬化),(ii)对表面剂量的影响,以及(iii)IQM探测器的衰减。

方法

对于6种不同的标称光子能量(4种标准能量,2种FFF能量)以及从1×1cm到20×20cm的方形射野尺寸,通过在射野路径中有/无IQM的情况下从百分深度剂量(PDD)曲线获得的PDD值,评估IQM对束流质量的影响。对于从4×4cm到20×20cm的所有可用能量和射野尺寸,评估有/无IQM时表面剂量的变化。通过测量所有可用能量和射野尺寸在10cm深度处的吸收剂量来计算传输因子。

结果

(i)观察到一种较小(0.11 - 0.53%)但具有统计学意义的束硬化效应,这取决于光子束能量。(ii)除18MV外,所有光子能量下表面剂量的增加与射野尺寸相关(p<0.01)。在所有情况下,表面剂量的变化小于3.3%,除了20×20cm射野和10MV FFF束,其表面剂量变化达到8.1%。(iii)对于标准束,IQM的传输对射野尺寸的依赖性较弱,对束流能量的依赖性较强(6MV时为0.9412,18MV时为0.9578,6MV FFF时为0.9440;10MV FFF时为0.9533)。

结论

发现IQM探测器对光子束特性的影响较小但具有统计学意义。所发现的变化幅度证明,可将IQM作为特定能量下治疗计划系统(TPS)中的托盘因子,或者作为直线加速器特定束流能量的修正输出,这便于将IQM引入临床实践。

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