Evangelista Perry J, Aversano Michael W, Koli Emmanuel, Hutzler Lorraine, Inneh Ifeoma, Bosco Joseph, Iorio Richard
Department of Orthopaedic Surgery, Hospital for Joint Diseases, NYU Langone Medical Centre, New York University Hospital for Joint Diseases, 301 E 17th Street, 14th Floor, New York, NY 10003, New York.
Department of Orthopaedic Surgery, Hospital for Joint Diseases, NYU Langone Medical Centre, New York University Hospital for Joint Diseases, 301 E 17th Street, 14th Floor, New York, NY 10003, New York.
Orthop Clin North Am. 2017 Apr;48(2):109-115. doi: 10.1016/j.ocl.2016.12.001. Epub 2017 Jan 30.
Tranexamic acid (TXA) is used to reduce blood loss in orthopedic total joint arthroplasty (TJA). This study evaluates the effectiveness of TXA in reducing transfusions and hospital cost in TJA. Participants undergoing elective TJA were stratified into 2 cohorts: those not receiving and those receiving intravenous TXA. TXA decreased total hip arthroplasty (THA) transfusions from 22.7% to 11.9%, and total knee arthroplasty (TKA) from 19.4% to 7.0%. The average direct hospital cost reduction for THA and TKA was $3083 and $2582, respectively. Implementation of a TJA TXA protocol significantly reduced transfusions in a safe and cost-effective manner.
氨甲环酸（TXA）用于减少骨科全关节置换术（TJA）中的失血。本研究评估了TXA在减少TJA输血和医院成本方面的有效性。接受择期TJA的参与者被分为2组：未接受静脉注射TXA的组和接受静脉注射TXA的组。TXA将全髋关节置换术（THA）的输血率从22.7%降至11.9%，将全膝关节置换术（TKA）的输血率从19.4%降至7.0%。THA和TKA的平均直接医院成本降低分别为3083美元和2582美元。实施TJA TXA方案以安全且具有成本效益的方式显著减少了输血。
