与缺氧诱导因子-1α相互作用的蛋白质汇编。
A compendium of proteins that interact with HIF-1α.
作者信息
Semenza Gregg L
机构信息
Johns Hopkins University School of Medicine, 733 N. Broadway, Baltimore, MD 21205 USA.
出版信息
Exp Cell Res. 2017 Jul 15;356(2):128-135. doi: 10.1016/j.yexcr.2017.03.041. Epub 2017 Mar 20.
Abstract
Hypoxia-inducible factor 1 (HIF-1) is the founding member of a family of transcription factors that function as master regulators of oxygen homeostasis. HIF-1 is composed of an O-regulated HIF-1α subunit and a constitutively expressed HIF-1β subunit. This review provides a compendium of proteins that interact with the HIF-1α subunit, many of which regulate HIF-1 activity in either an O-dependent or O-independent manner.
摘要
缺氧诱导因子1（HIF-1）是转录因子家族的创始成员，作为氧稳态的主要调节因子发挥作用。HIF-1由一个氧调节的HIF-1α亚基和一个组成型表达的HIF-1β亚基组成。本综述提供了与HIF-1α亚基相互作用的蛋白质汇总，其中许多蛋白质以氧依赖或氧非依赖方式调节HIF-1活性。
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2
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Nat Commun. 2016 Dec 9;7:13644. doi: 10.1038/ncomms13644.
3
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