Katoh S, Hayakawa K, Tsuchiya M, Arai M, Kazumoto T, Niibe H, Tamura M
Dept. of Radiology, Gunma Univ. School of Med.
Gan No Rinsho. 1988 Apr;34(4):411-5.
The results of radiation therapy in 31 patients with intracranial germ cell tumors have been analyzed. The five-year survival rates were 70.1% for germinomas and 38.1% for teratomas. Three patients with germinoma have since died of spinal seeding. The prophylactic irradiation of the spinal canal has been found effective in protecting spinal seeding, since no relapse of germinoma has been observed in cases that received entire neuraxis irradiation, whereas teratomas and marker (AFP, HCG) positive tumors did not respond favorably to radiation therapy, and the cause of death in these patients has been local failure. Long-term survivors over 3 years after radiation therapy have been determined as having a good quality of life.
对31例颅内生殖细胞瘤患者的放射治疗结果进行了分析。生殖细胞瘤的五年生存率为70.1%，畸胎瘤为38.1%。3例生殖细胞瘤患者后来死于脊髓播散。已发现对椎管进行预防性照射可有效预防脊髓播散，因为在接受全神经轴照射的病例中未观察到生殖细胞瘤复发，而畸胎瘤和标志物（甲胎蛋白、人绒毛膜促性腺激素）阳性肿瘤对放射治疗反应不佳，这些患者的死亡原因是局部治疗失败。放疗后存活超过3年的长期存活者被确定为生活质量良好。
