Corwin William L, Ebrahimi-Nik Hakimeh, Floyd Stephanie M, Tavousi Pouya, Mandoiu Ion I, Srivastava Pramod K
Department of Immunology, and Carole and Ray Neag Comprehensive Cancer Center, University of Connecticut School of Medicine, Farmington, CT, United States.
Department of Pharmaceutical Science, University of Connecticut, School of Pharmacy, Storrs, CT, United States.
J Immunol Methods. 2017 Jun;445:71-76. doi: 10.1016/j.jim.2017.03.013. Epub 2017 Mar 20.
Measurement of tumor diameters, tumor volumes, or area under the curve has been traditionally used to quantitate and compare tumor growth curves in immune competent as well as immune-compromised mice and rats. Here, using tumor growth data from a large number of mice challenged with live tumor cells, we describe the use of a new composite parameter, Tumor Control Index (TCI) as an alternative method to do the same. This index, comprised of three distinct values, the Tumor Inhibition Score, Tumor Rejection Score, and Tumor Stability Score, provides a complete picture of nearly every aspect of tumor growth in large numbers of animals, can be deduced automatically from tumor diameter or volume data, and can be used to compare several groups of animals in different experiments. This automatically derivable index also corresponds neatly to the use of complete and partial responses and tumor stability data generated in human tumors, and can be used to assess the efficacy of interventions to be used in clinical studies.
传统上，人们通过测量肿瘤直径、肿瘤体积或曲线下面积来定量和比较免疫功能正常以及免疫受损的小鼠和大鼠的肿瘤生长曲线。在此，我们利用大量接种活肿瘤细胞的小鼠的肿瘤生长数据，描述了一种新的综合参数——肿瘤控制指数（TCI）的使用方法，作为实现相同目的的替代方法。该指数由三个不同的值组成，即肿瘤抑制评分、肿瘤排斥评分和肿瘤稳定性评分，能全面反映大量动物肿瘤生长几乎各个方面的情况，可根据肿瘤直径或体积数据自动推导得出，还可用于比较不同实验中的几组动物。这个可自动推导的指数也与人类肿瘤中产生的完全缓解、部分缓解和肿瘤稳定性数据的使用情况紧密对应，可用于评估临床研究中所用干预措施的疗效。
