Li Qiji, Ye Liping, Guo Wei, Wang Min, Huang Shuai, Peng Xinsheng
Department of Orthopaedic Surgery, The First Affiliated Hospital of Sun Yat-sen University, 510080, Guangzhou, Guangdong Province, China; Guangdong Provincial Key Laboratory of Orthopedics and Traumatology, 510080, Guangzhou, Guangdong Province, China.
Department of Experimental Research, State Key Laboratory of Oncology in Southern China, Sun Yat-sen University Cancer Center, 510060, Guangzhou, Guangdong Province, China.
Biochem Biophys Res Commun. 2017 May 13;486(4):872-878. doi: 10.1016/j.bbrc.2017.03.090. Epub 2017 Mar 20.
Transforming acidic coiled-coil (TACC3), a member of the TACC family, has been shown to be deregulated in various cancers and involved in tumor progression. However, its biological role and molecular mechanism in prostate cancer (PCa) have not been elucidated. Herein, we reported that TACC3 was markedly upregulated in metastatic PCa. The upregulation of TACC3 was significantly associated with the metastasis status, tumor stage, total prostate-specific antigen (PSA) level, and Gleason score in patients with PCa. Moreover, a Kaplan-Meier survival analysis showed that patients with PCa who had high TACC3 expression experienced shorter disease-free survival than patients with a low TACC3 expression. In addition, the knockdown of TACC3 dramatically reduced the migratory speed and invasiveness of PCa cells. Furthermore, silencing TACC3 markedly suppressed the Wnt/β-catenin signaling pathway. Taken together, these findings uncover a supportive role for TACC3 in PCa metastasis, which is mediated by the activation of the Wnt/β-catenin signaling pathway, suggesting that TACC3 may serve as a prognostic marker in patients with metastatic PCa.
转化酸性卷曲螺旋蛋白3（TACC3）是TACC家族的成员之一，已证实在多种癌症中表达失调，并参与肿瘤进展。然而，其在前列腺癌（PCa）中的生物学作用和分子机制尚未阐明。在此，我们报道TACC3在转移性PCa中显著上调。TACC3的上调与PCa患者的转移状态、肿瘤分期、总前列腺特异性抗原（PSA）水平和Gleason评分显著相关。此外，Kaplan-Meier生存分析表明，TACC3高表达的PCa患者的无病生存期短于TACC3低表达的患者。此外，敲低TACC3可显著降低PCa细胞的迁移速度和侵袭能力。此外，沉默TACC3可显著抑制Wnt/β-连环蛋白信号通路。综上所述，这些发现揭示了TACC3在PCa转移中的支持作用，这是由Wnt/β-连环蛋白信号通路的激活介导的，表明TACC3可能作为转移性PCa患者的预后标志物。
