Huo Qin, Chen Siqi, Li Zhenwei, Wang Juan, Li Jiaying, Xie Ni
Biobank, Institute of Translational medicine, Shenzhen Second People's Hospital, Graduate School of Guangzhou Medical University, Shenzhen, China.
Department of Clinical Medicine, University of South China, Hengyang, China.
Front Genet. 2021 Jun 3;12:640078. doi: 10.3389/fgene.2021.640078. eCollection 2021.
Accumulating evidences indicate that transforming acidic coiled-coil 3 (TACC3) is a tumor-related gene, was highly expressed in a variety of human cancers, which is involved in cancer development. However, the potential role of TACC3 in breast cancer remains largely unknown. In the present study, we found that TACC3 was highly-expressed in breast cancer tissues, and its level was positively correlated with the clinical features of breast cancer patients. Specifically, TACC3 expression was significantly associated with the estrogen receptor (ER), progesterone receptor (PR), human epidermal growth factor receptor 2 (HER2) status, nodal status, the scarff-bloom-richardson (SBR) grade, nottingham prognostic index (NPI), age, subtypes, and triple-negative and basal-like status, suggesting that TACC3 may be a potential diagnostic indicator of breast cancer. Furthermore, functional studies have shown that inhibition of TACC3 can significantly promote the cell proliferation and viability of breast cancer cells. Moreover, TACC3 knockdown suppressed the expression of E-cadherin, but increased the expression of N-cadherin, Snail, ZEB1, and TWIST, which indicate that TACC3 may impact the migration of breast cancer cells . Taken together, these findings indicate that TACC3 may serve as a prognostic and therapeutic indicator of breast cancer.
越来越多的证据表明，转化酸性卷曲螺旋蛋白3（TACC3）是一种肿瘤相关基因，在多种人类癌症中高表达，参与癌症发展。然而，TACC3在乳腺癌中的潜在作用仍 largely未知。在本研究中，我们发现TACC3在乳腺癌组织中高表达，其水平与乳腺癌患者的临床特征呈正相关。具体而言，TACC3表达与雌激素受体（ER）、孕激素受体（PR）、人表皮生长因子受体2（HER2）状态、淋巴结状态、斯卡夫-布卢姆-理查森（SBR）分级、诺丁汉预后指数（NPI）、年龄、亚型以及三阴性和基底样状态显著相关，提示TACC3可能是乳腺癌的潜在诊断指标。此外，功能研究表明，抑制TACC3可显著促进乳腺癌细胞的增殖和活力。而且，TACC3基因敲低抑制了E-钙黏蛋白的表达，但增加了N-钙黏蛋白、Snail、ZEB1和TWIST的表达，这表明TACC3可能影响乳腺癌细胞的迁移。综上所述，这些发现表明TACC3可能作为乳腺癌的预后和治疗指标。
