Turcu Ioana, Zarafu Irina, Popa Marcela, Chifiriuc Mariana Carmen, Bleotu Coralia, Culita Daniela, Ghica Corneliu, Ionita Petre
Department of Organic Chemistry, Biochemistry and Catalysis, University of Bucharest, 90-92 Panduri, 050663 Bucharest, Romania.
Microbiology Department, Faculty of Biology, University of Bucharest, 1-3 Portocalelor Way, 060101 Bucharest, Romania.
Nanomaterials (Basel). 2017 Feb 16;7(2):43. doi: 10.3390/nano7020043.
Water soluble gold nanoparticles protected by lipoic acid were obtained and further functionalized by standard coupling reaction with 1-naphtylamine, 4-aminoantipyrine, and 4'-aminobenzo-15-crown-5 ether. Derivatives of lipoic acid with 1-naphtylamine, 4-aminoantipyrine, and 4'-aminobenzo-15-crown-5 ether were also obtained and characterized. All these were tested for their antimicrobial activity, as well as for their influence on mammalian cell viability and cellular cycle. In all cases a decreased antimicrobial activity of the obtained bioactive nanoparticles was observed as compared with the organic compounds, proving that a possible inactivation of the bioactive groups could occur during functionalization. However, both the gold nanoparticles as well as the functionalized bioactive nanosystems proved to be biocompatible at concentrations lower than 50 µg/mL, as revealed by the cellular viability and cell cycle assay, demonstrating their potential for the development of novel antimicrobial agents.
获得了由硫辛酸保护的水溶性金纳米颗粒，并通过与1-萘胺、4-氨基安替比林和4'-氨基苯并-15-冠-5醚的标准偶联反应进一步功能化。还获得并表征了硫辛酸与1-萘胺、4-氨基安替比林和4'-氨基苯并-15-冠-5醚的衍生物。对所有这些进行了抗菌活性测试，以及它们对哺乳动物细胞活力和细胞周期的影响测试。在所有情况下，与有机化合物相比，观察到所获得的生物活性纳米颗粒的抗菌活性降低，证明在功能化过程中可能发生生物活性基团的失活。然而，细胞活力和细胞周期分析表明，金纳米颗粒以及功能化的生物活性纳米系统在浓度低于50μg/mL时都具有生物相容性，证明了它们在开发新型抗菌剂方面的潜力。
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