Temur Nimet, Dadi Seyma, Dogan Ayse Nur, Nisari Mustafa, Avan Ilker, Ocsoy Ismail
Department of Analytical Chemistry, Faculty of Pharmacy, Erciyes University, Kayseri 38039, Turkey.
Department of Materials Science and Nanotechnology Engineering, Abdullah Gül University, Kayseri 38080, Turkey.
ACS Omega. 2025 Apr 8;10(15):15484-15492. doi: 10.1021/acsomega.5c00274. eCollection 2025 Apr 22.
In this work, we rationally synthesized quite stable gold nanoparticles (AuNPs) using dihydrolipoic acid (DHLA) and DHLA-aspartame (DHLA-Asptm) as both reducing and stabilizing agents in a mixture of water/ethanol at RT under photoirradiation in 10 min. The novelty of this work is that benefiting from both the oxidation of ethanol to ethanal and having the bidentate thiol groups of DHLA, stable DHLA@AuNPs and DHLA-Asptm@AuNPs were successfully and rapidly formed without additional reducing reagents. We systematically examined the formation of DHLA@AuNPs and DHLA-Asptm@AuNPs under different pH values and reaction temperatures. Furthermore, the salt tolerance of DHLA@AuNPs and DHLA-Asptm@AuNPs was tested in a series of sodium chloride solutions. We showed the catalytic and peroxidase-like activities of DHLA@AuNPs against 4-nitrophenol and 3,3',5,5'-tetramethylbenzidine. The AuNPs were characterized by UV-vis spectrophotometry, scanning transmission electron microscopy, zeta potential, and dynamic light scattering.
在这项工作中，我们在室温下，于水/乙醇混合溶液中，利用二氢硫辛酸（DHLA）和二氢硫辛酸 - 阿斯巴甜（DHLA - Asptm）作为还原和稳定剂，在光照下10分钟内合理地合成了相当稳定的金纳米颗粒（AuNPs）。这项工作的新颖之处在于，得益于乙醇氧化为乙醛以及DHLA的双齿硫醇基团，无需额外的还原剂就能成功且快速地形成稳定的DHLA@AuNPs和DHLA - Asptm@AuNPs。我们系统地研究了在不同pH值和反应温度下DHLA@AuNPs和DHLA - Asptm@AuNPs的形成。此外，还在一系列氯化钠溶液中测试了DHLA@AuNPs和DHLA - Asptm@AuNPs的耐盐性。我们展示了DHLA@AuNPs对4 - 硝基苯酚和3,3',5,5' - 四甲基联苯胺的催化活性和类过氧化物酶活性。通过紫外 - 可见分光光度法、扫描透射电子显微镜、zeta电位和动态光散射对AuNPs进行了表征。
