Chai Chunxiao, Zhang Pengfei, Ma Lin, Fan Qi, Liu Zhicheng, Cheng Xiang, Zhao Yunpeng, Li Weiwei, Hao Jingcheng
Key Laboratory of Colloid and Interface Chemistry (Shandong University), Ministry of Education, Jinan, 250100, PR China.
Department of Orthopaedic Surgery, Qilu Hospital, Cheeloo College of Medicine, Shandong University, Jinan, 250012, PR China.
Bioact Mater. 2022 Aug 8;25:541-554. doi: 10.1016/j.bioactmat.2022.07.020. eCollection 2023 Jul.
Hydrogel products for chronic diabetic wounds, a serious and prevalent complication of diabetes, show limited effects on disability and remain nonspecific. Thus, improvements in the usage of pharmaceutical molecule in the hydrogels are highly desirable to increase the therapeutic effect of hydrogels. In this study, thioctic acid (a common medicine molecule in diabetes treatment) is used for preparing regenerative antibacterial hydrogels (RAH) which contains synthesized silver nanoparticles (AgNPs). The RAH shows regenerative, self-healing and injectable ability, because of the reversible hydrogen and coordination bonds. With good regenerative capacity, RAH can be stored as powder to avoid the water loss and facilitate storage availability. Owing to the antioxidant properties of thioctic acid, the RAH can decrease the oxidative damage and retain cell proliferation efficiency. Due to the synthesized AgNPs, the RAH also exhibits extraordinary antimicrobial capacities against MDR bacteria. All of these superiorities enable RAH to be a promising therapy for chronic diabetic wounds.
用于慢性糖尿病伤口（糖尿病一种严重且常见的并发症）的水凝胶产品，对残疾的影响有限且仍缺乏特异性。因此，非常需要改进水凝胶中药物分子的使用方式，以提高水凝胶的治疗效果。在本研究中，硫辛酸（糖尿病治疗中一种常用药物分子）被用于制备含有合成银纳米颗粒（AgNPs）的再生抗菌水凝胶（RAH）。由于存在可逆的氢键和配位键，RAH具有再生、自愈和可注射的能力。凭借良好的再生能力，RAH可以以粉末形式储存，以避免水分流失并便于储存。由于硫辛酸的抗氧化特性，RAH可以减少氧化损伤并保持细胞增殖效率。由于合成了AgNPs，RAH对多重耐药菌也具有非凡的抗菌能力。所有这些优势使RAH成为治疗慢性糖尿病伤口的一种有前景的疗法。
