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未分化与肝源性部分分化间充质干细胞对肝硬化患者肝脏及认知功能的影响

Effect of undifferentiated versus hepatogenic partially differentiated mesenchymal stem cells on hepatic and cognitive functions in liver cirrhosis.

作者信息

Elberry Dalia Azmy, Amin Shaimaa Nasr, Esmail Reham Shehab El Nemr, Rashed Laila Ahmed, Gamal Maha Mohamed

机构信息

Department of Medical Physiology, Kasr Al Ainy Faculty of Medicine, Cairo University, Egypt.

Department of Pathology, Faculty of Medicine, Fayoum University, Fayoum, Egypt.

出版信息

EXCLI J. 2016 Nov 7;15:652-670. doi: 10.17179/excli2016-645. eCollection 2016.

DOI:10.17179/excli2016-645
PMID:28337098
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC5318675/
Abstract

Liver cirrhosis is the outcome of chronic liver injury. The current study aimed to investigate the therapeutic effect of undifferentiated mesenchymal stem cells versus partially differentiated mesenchymal stem cells on liver cirrhosis and hepatic encephalopathy. 50 adult male albino rats constituted the animal model and were divided into the following groups: control, thioacetamide, undifferentiated mesenchymal stem cells and hepatocyte growth factor-differentiated mesenchymal stem cells groups. Cognitive assessment was achieved by open field test and Y-maze task. We measured serum alanine aminotransferase, albumin and transforming growth factor-beta1, gene expression of α-smooth muscle actin, matrix metalloprotein-2, its tissue inhibitor and apoptotic markers: Bax and Bcl2, brain glial fibrillary acidic protein, synaptophysin, and dopaminergic receptors.

摘要

肝硬化是慢性肝损伤的结果。本研究旨在探讨未分化间充质干细胞与部分分化间充质干细胞对肝硬化和肝性脑病的治疗效果。50只成年雄性白化大鼠构成动物模型，并分为以下几组：对照组、硫代乙酰胺组、未分化间充质干细胞组和肝细胞生长因子分化间充质干细胞组。通过旷场试验和Y迷宫任务进行认知评估。我们检测了血清丙氨酸转氨酶、白蛋白和转化生长因子-β1、α-平滑肌肌动蛋白、基质金属蛋白酶-2及其组织抑制剂的基因表达以及凋亡标志物：Bax和Bcl2、脑胶质纤维酸性蛋白、突触素和多巴胺能受体。

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Deficit of astroglia-derived thrombospondin-1 and loss of synaptic proteins in hepatic encephalopathy: do ammonia-overexposed astrocytes derange the synaptic hardware?肝性脑病中星形胶质细胞源性血小板反应蛋白-1缺乏与突触蛋白丢失：氨过度暴露的星形胶质细胞是否扰乱了突触结构？
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Co-treatment with grape seed extract and mesenchymal stem cells in vivo regenerated beta cells of islets of Langerhans in pancreas of type I-induced diabetic rats.体内共处理葡萄籽提取物和间充质干细胞可在 I 型糖尿病大鼠胰岛的胰岛中再生β细胞。
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Effect of Allopregnanolone on Spatial Memory and Synaptic Proteins in Animal Model of Metabolic Syndrome.别孕烯醇酮对代谢综合征动物模型空间记忆和突触蛋白的影响。
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