Notch信号通路在胰腺癌中的作用。
Role of Notch signaling pathway in pancreatic cancer.
作者信息
Gao Jiankun, Long Bo, Wang Zhiwei
机构信息
Sichuan College of Tranditional Chinese Medicine Mianyang, Sichuan, China.
Department of Infectious Diseases, Mianyang 404 Hospital Mianyang, Sichuan, China.
出版信息
Am J Cancer Res. 2017 Feb 1;7(2):173-186. eCollection 2017.
Abstract
Pancreatic cancer (PC) is one of the highly aggressive malignancies in the United States. It has been shown that multiple signaling pathways are involved in the pathogenesis of PC, such as JNK, PI3K/AKT, Rho GTPase, Hedgehog (Hh) and Skp2. In recent years, accumulated evidence has demonstrated that Notch signaling pathway plays critical roles in the development and progression of PC. Therefore, in this review we discuss the recent literature regarding the function and regulation of Notch in the pathogenesis of PC. Moreover, we describe that Notch signaling pathway could be down-regulated by its inhibitors or natural compounds, which could be a novel approach for the treatment of PC patients.
摘要
胰腺癌（PC）是美国侵袭性很强的恶性肿瘤之一。研究表明，多种信号通路参与了胰腺癌的发病机制，如JNK、PI3K/AKT、Rho GTP酶、刺猬蛋白（Hh）和Skp2。近年来，越来越多的证据表明Notch信号通路在胰腺癌的发生和发展中起关键作用。因此，在本综述中，我们讨论了关于Notch在胰腺癌发病机制中的功能和调控的最新文献。此外，我们描述了Notch信号通路可被其抑制剂或天然化合物下调，这可能是治疗胰腺癌患者的一种新方法。
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