Shimamura Yuto, Hwang Jason, Cirocco Maria, May Gary R, Mosko Jeffrey, Teshima Christopher W
Division of Gastroenterology, St. Michael's Hospital, University of Toronto, Toronto, Ontario, Canada.
Division of Gastroenterology, St. Michael's Hospital, University of Toronto, Toronto, Ontario, Canada; Division of Gastroenterology, The Wesley Hospital, Auchenflower, Australia.
Endosc Int Open. 2017 Jan;5(1):E5-E10. doi: 10.1055/s-0042-122334.
Single-incision needle-knife (SINK) biopsy is a diagnostic method for acquiring tissue samples for subepithelial lesions (SELs). A single linear incision is made in the overlying mucosa and tissue samples are obtained by passing conventional biopsy forceps through the opening and deep into the lesion. The aim of this study was to describe the efficacy and safety of this technique. Consecutive patients who underwent SINK biopsy for an upper gastrointestinal SEL between October 2013 and September 2015 were retrospectively reviewed. Forty-nine patients underwent 50 SINK biopsies. Sufficient sampling for a definite pathologic diagnosis was obtained in 42 (86 %) cases, with 91 % (40/44) having sufficient sample to perform immunohistochemistry when deemed clinically relevant. Of the 26 patients with prior non-diagnostic biopsies or FNA, a specific diagnosis was obtained in 85 % (22/26). There were no significant adverse events. SINK biopsy is a safe and feasible strategy for obtaining a definitive tissue diagnosis with immunohistochemistry for SELs.
单切口针刀活检是一种获取上皮下病变（SELs）组织样本的诊断方法。在上覆黏膜上做一个单一的线性切口，通过常规活检钳经该切口深入病变部位获取组织样本。本研究的目的是描述该技术的有效性和安全性。对2013年10月至2015年9月期间因上消化道SELs接受单切口针刀活检的连续患者进行回顾性分析。49例患者接受了50次单切口针刀活检。42例（86%）病例获得了足够的样本用于明确病理诊断，其中91%（40/44）在临床认为有必要时获得了足够的样本进行免疫组化检查。在26例先前活检或细针穿刺抽吸未明确诊断的患者中，85%（22/26）获得了明确诊断。无明显不良事件。单切口针刀活检是一种安全可行的策略，可通过免疫组化对SELs进行明确的组织诊断。
