Suppr超能文献

心力衰竭患者的维生素 D 缺乏症:对功能能力和患者生存的影响。

Hypovitaminosis D in patients with heart failure: effects on functional capacity and patients' survival.

机构信息

Scuola Superiore Sant'Anna, Pisa, Italy.

Endocrinology Unit 2, University of Pisa, Pisa, Italy.

出版信息

Endocrine. 2017 Dec;58(3):574-581. doi: 10.1007/s12020-017-1282-9. Epub 2017 Mar 23.

Abstract

Chronic heart failure is a major cause of morbidity and mortality, but its prognosis remains poor. Vitamin D hormone has many extra-skeletal functions including a positive impact on the cardiovascular system, and has been proposed for mortality risk evaluation in heart failure patients. The aim of the present study was to evaluate vitamin D status in heart failure patients, measured by high performance liquid chromatography coupled with mass spectrometry and to correlate serum 25 hydroxy-vitamin D (25OHD) levels with functional (peak VO%) and mortality (Metabolic Exercise Cardiac Kidney Index) heart failure parameters. We enrolled 261 consecutive patients diagnosed with heart failure; all patients underwent a comprehensive clinical and biochemical characterization, and serum 25OHD levels were measured by high performance liquid chromatography coupled with mass spectrometry. Cardiopulmonary test parameters and Metabolic Exercise Cardiac Kidney Index of mortality risk were measured in all patients. Serum 25OHD levels ranged between 2 and 45 ng/ml (mean 17 ± 9 ng/ml); most patients (87%) showed hypovitaminosis D, and 25% showed severe vitamin D deficiency (serum 25OHD < 10 ng/ml). Patients with 25OHD < 10 ng/ml had significantly lower cardiopulmonary test VO/kg, peak VO% and significantly higher N-terminalproBrain natriuretic peptide and Metabolic Exercise Cardiac Kidney Index, than patients with 25OHD > 10 ng/ml. Patients with peak VO% < 50% showed significantly lower 25OHD compared to those with peak VO% > 50%. There was a significant, positive correlation (r = 0.16, p = 0.008) between 25OHD levels and peak VO%, and an inverse correlation with Metabolic Exercise Cardiac Kidney Index (r = -0.21, p < 0.001), even when adjusted for age, Body Mass Index, MDRD, N-terminalproBrain natriuretic peptide. In conclusion, our findings show that vitamin D levels are associated with functional and mortality heart failure prognosis parameters.

摘要

慢性心力衰竭是发病率和死亡率的主要原因,但预后仍然较差。维生素 D 激素具有许多骨骼外功能,包括对心血管系统的积极影响,并已被提议用于心力衰竭患者的死亡风险评估。本研究旨在通过高效液相色谱-质谱联用评估心力衰竭患者的维生素 D 状态,并将血清 25 羟基维生素 D(25OHD)水平与功能(峰值 VO%)和死亡率(代谢运动心脏肾脏指数)心力衰竭参数相关联。我们纳入了 261 例连续诊断为心力衰竭的患者;所有患者均接受了全面的临床和生化特征描述,并通过高效液相色谱-质谱联用测量了血清 25OHD 水平。所有患者均测量了心肺测试参数和代谢运动心脏肾脏指数的死亡率风险。血清 25OHD 水平在 2 至 45ng/ml 之间(平均值为 17±9ng/ml);大多数患者(87%)表现为维生素 D 缺乏症,25%表现为严重维生素 D 缺乏症(血清 25OHD<10ng/ml)。血清 25OHD<10ng/ml 的患者心肺测试 VO/kg、峰值 VO%显著较低,N 端脑钠肽前体和代谢运动心脏肾脏指数显著较高,而血清 25OHD>10ng/ml 的患者则相反。峰值 VO%<50%的患者 25OHD 显著低于峰值 VO%>50%的患者。25OHD 水平与峰值 VO%呈显著正相关(r=0.16,p=0.008),与代谢运动心脏肾脏指数呈负相关(r=-0.21,p<0.001),即使在调整年龄、体重指数、MDRD、N 端脑钠肽前体后也是如此。总之,我们的研究结果表明,维生素 D 水平与心力衰竭的功能和死亡率预后参数相关。

文献AI研究员

20分钟写一篇综述,助力文献阅读效率提升50倍。

立即体验

用中文搜PubMed

大模型驱动的PubMed中文搜索引擎

马上搜索

文档翻译

学术文献翻译模型,支持多种主流文档格式。

立即体验