Jothimani B, Sureshkumar S, Venkatachalapathy B
Department of Chemistry, Rajalakshmi Engineering College, Thandalam, Chennai, 602105, India.
SRM Easwari Engineering College, Ramapuram, Chennai, 600089, India.
J Fluoresc. 2017 Jul;27(4):1277-1284. doi: 10.1007/s10895-017-2059-5. Epub 2017 Mar 23.
The introduction of a hydrophobic moiety on chitosan enhances the self-assembling properties, mucoadhesion, the permeability of the macromolecule and aids in target specific delivery. Our group synthesized a hydrophobic trans N-(6,6-Dimethyl-2-hepten-4-ynyl)chitosan derivative (CSD) and studied the surface modification of ZnS nanoparticles in a single pot reaction. X-ray diffraction studies and FESEM imaging confirms the nano size and morphology of the surface modified Zinc sulfide nanoparticles (ZnS-CSD NPs). The proposed ZnS-CSD NPs showed excellent emission at 457 nm. Photostability studies indicate that the surface modified ZnS-CSD NPs possess better photostability than Rhodamine B and FITC. Cell viability tests confirmed the biocompatibility of the modified nanoparticles. All these features of ZnS- CSD NPs makes these candidates an excellent choice in a wide range of in vitro or in vivo studies as fluorescent biological labels.
在壳聚糖上引入疏水部分可增强其自组装性能、粘膜粘附性、大分子的渗透性，并有助于靶向特异性递送。我们小组合成了一种疏水反式N-(6,6-二甲基-2-庚烯-4-炔基)壳聚糖衍生物(CSD)，并研究了在单锅反应中硫化锌纳米颗粒的表面改性。X射线衍射研究和场发射扫描电子显微镜成像证实了表面改性硫化锌纳米颗粒(ZnS-CSD NPs)的纳米尺寸和形态。所提出的ZnS-CSD NPs在457 nm处显示出优异的发射。光稳定性研究表明，表面改性的ZnS-CSD NPs比罗丹明B和异硫氰酸荧光素具有更好的光稳定性。细胞活力测试证实了改性纳米颗粒的生物相容性。ZnS-CSD NPs的所有这些特性使其成为广泛的体外或体内研究中作为荧光生物标记物候选的绝佳选择。
