Bose Mihika, Kamra Mohini, Mullick Ranajoy, Bhattacharya Santanu, Das Saumitra, Karande Anjali A
Department of Biochemistry, Indian Institute of Science, Bangalore, India.
Department of Organic Chemistry, Indian Institute of Science, Bangalore, India.
FEBS Lett. 2017 May;591(9):1305-1317. doi: 10.1002/1873-3468.12629. Epub 2017 Apr 13.
Emergence of drug-resistant viruses, high cost and adverse side-effects associated with the standard therapy against hepatitis C virus (HCV) infection demonstrate the need for development of well tolerated and effective antivirals. We identified and chemically characterised the dehydrorotenoid boeravinone H, isolated from the herb Boerhavia diffusa, as a new inhibitor of HCV entry. The compound significantly inhibits the binding and entry of hepatitis C-like particles (HCV-LPs) in hepatoma cells in vitro with no apparent cytotoxicity. Boeravinone H inhibits the initial phase of HCV entry probably by acting directly on the viral particle. Importantly, the compound prevents HCV entry and infection in cell culture (ex vivo). Thus, boeravinone H is a potential antiviral agent for the prevention and control of HCV infection.
耐药性病毒的出现、与丙型肝炎病毒（HCV）感染标准疗法相关的高成本和不良副作用表明，需要开发耐受性良好且有效的抗病毒药物。我们从草药胀果甘草中分离出脱水类胡萝卜素波叶大黄素H，并对其进行了化学表征，发现它是一种新的HCV进入抑制剂。该化合物在体外能显著抑制肝癌细胞中丙型肝炎样颗粒（HCV-LPs）的结合和进入，且无明显细胞毒性。波叶大黄素H可能通过直接作用于病毒颗粒来抑制HCV进入的初始阶段。重要的是，该化合物可在细胞培养（体外）中阻止HCV进入和感染。因此，波叶大黄素H是预防和控制HCV感染的潜在抗病毒药物。
