Celli R, Schulz W, Hendrickson J E, Tormey C A
Department of Laboratory Medicine, Yale University School of Medicine, New Haven, CT, USA.
Department of Pediatrics, Yale University School of Medicine, New Haven, CT, USA.
Vox Sang. 2017 Jul;112(5):469-472. doi: 10.1111/vox.12515. Epub 2017 Mar 23.
We hypothesized that diagnoses may be associated with alloantibody 'responder' status and examined associations between disease states and alloimmunization. Patients with ≥1 alloantibody and non-alloimmunized controls were analysed. Pearson's coefficients were calculated to determine associations between alloimmunization and diseases; significant correlations were selected to construct a network. Inflammatory disorders and diseases requiring chronic transfusion support were associated with responder status. Mitigation steps may be considered in patients with these disorders.
我们假设诊断结果可能与同种抗体“反应者”状态相关，并研究了疾病状态与同种免疫之间的关联。对有≥1种同种抗体的患者和未发生同种免疫的对照者进行了分析。计算皮尔逊系数以确定同种免疫与疾病之间的关联；选择显著相关性来构建一个网络。炎症性疾病和需要长期输血支持的疾病与反应者状态相关。对于患有这些疾病的患者，可考虑采取缓解措施。
