Kawata Satoshi, Ichimura Taro, Taguchi Atsushi, Kumamoto Yasuaki
Department of Applied Physics, Osaka University , Osaka 565-0871, Japan.
Quantitative Biology Center, RIKEN , Osaka 565-0874, Japan.
Chem Rev. 2017 Apr 12;117(7):4983-5001. doi: 10.1021/acs.chemrev.6b00560. Epub 2017 Mar 24.
Raman scattering microscopy is becoming one of the hot topics in analytical microscopy as a tool for analyzing advanced nanomaterials, such as biomolecules in a live cell for the study of cellular dynamics, semiconductor devices for characterizing strain distribution and contamination, and nanocarbons and nano-2D materials. In this paper, we review the recent progress in the development of Raman scattering microscopy from the viewpoint of spatial resolution and scattering efficiency. To overcome the extremely small cross section of Raman scattering, we discuss three approaches for the enhancement of scattering efficiency and show that the scattering enhancement synergistically increases the spatial resolution. We discuss the mechanisms of tip-enhanced Raman scattering, deep-UV resonant Raman scattering, and coherent nonlinear Raman scattering for micro- and nanoscope applications. The combinations of these three approaches are also shown as nanometer-resolution Raman scattering microscopy. The critical issues of the structures, materials, and reproducibility of tips and three-dimensionality for TERS; photodegradation for resonant Raman scattering; and laser availability for coherent nonlinear Raman scattering are also discussed.
拉曼散射显微镜作为一种分析先进纳米材料的工具，正成为分析显微镜领域的热门话题之一，这些纳米材料包括用于研究细胞动力学的活细胞中的生物分子、用于表征应变分布和污染的半导体器件，以及纳米碳和二维纳米材料。在本文中，我们从空间分辨率和散射效率的角度综述了拉曼散射显微镜发展的最新进展。为了克服拉曼散射截面极小的问题，我们讨论了三种提高散射效率的方法，并表明散射增强协同提高了空间分辨率。我们讨论了用于微米和纳米显微镜应用的针尖增强拉曼散射、深紫外共振拉曼散射和相干非线性拉曼散射的机制。这三种方法的组合也被展示为纳米分辨率拉曼散射显微镜。还讨论了针尖增强拉曼散射（TERS）的结构、材料、针尖的重现性和三维性的关键问题；共振拉曼散射的光降解问题；以及相干非线性拉曼散射的激光可用性问题。
