Bunker M L, Chewning L, Wang S E, Gordon M A
Department of Surgical Pathology, Allegheny General Hospital, Pittsburgh, Pennsylvania.
Am J Clin Pathol. 1988 May;89(5):683-7. doi: 10.1093/ajcp/89.5.683.
The authors report the first human case (to our knowledge) of infection of the oral mucosa by Dermatophilus congolensis. Septate branching filaments morphologically identical to those of D. congolensis were identified in the lingual epithelium of a male homosexual employed as an animal handler. This actinomycete is the cause of dermatophilosis, a proliferative exudative dermatitis affecting many animal species. Clinical features suggested "hairy" leukoplakia (HL), a hyperkeratotic tongue lesion for which human papillomavirus (HPV) and Epstein-Barr virus (EBV) have been implicated as etiologic agents. Immunoperoxidase staining for HPV capsid antigen was negative. Direct immunofluorescent staining with a conjugate specific for D. congolensis identified the bacterial structures as those of this species while excluding morphologically similar organisms.
据作者所知，本文报道了首例刚果嗜皮菌感染口腔黏膜的人类病例。在一名从事动物饲养员工作的男性同性恋者的舌上皮中，发现了形态上与刚果嗜皮菌相同的分隔分支细丝。这种放线菌是嗜皮菌病的病原体，嗜皮菌病是一种影响多种动物的增殖性渗出性皮炎。临床特征提示为“毛状”白斑（HL），这是一种舌部角化过度病变，人乳头瘤病毒（HPV）和爱泼斯坦-巴尔病毒（EBV）被认为是其病原体。HPV衣壳抗原的免疫过氧化物酶染色为阴性。用针对刚果嗜皮菌的特异性结合物进行直接免疫荧光染色，确定细菌结构为该菌种，同时排除了形态相似的生物体。
