Ma Xiaojie, Zhu Saiyong
Life Sciences Institute, Zhejiang University, Hangzhou 310058, China.
Acta Biochim Biophys Sin (Shanghai). 2017 Apr 1;49(4):289-301. doi: 10.1093/abbs/gmx008.
Generation of unlimited functional pancreatic β cells is critical for the study of pancreatic biology and treatment of diabetes mellitus. Recent advances have suggested several promising directions, including directed differentiation of pancreatic β cells from pluripotent stem cells, reprogramming of pancreatic β cells from other types of somatic cells, and stimulated proliferation and enhanced functions of existing pancreatic β cells. Small molecules are useful in generating unlimited numbers of functional pancreatic cells in vitro and could be further developed as drugs to stimulate endogenous pancreatic regeneration. Here, we provide an updated summary of recent major achievements in pancreatic β cell differentiation, reprogramming, proliferation, and function. These studies will eventually lead to significant advances in the field of pancreatic biology and regeneration.
生成无限数量的功能性胰腺β细胞对于胰腺生物学研究和糖尿病治疗至关重要。最近的进展提出了几个有前景的方向，包括从多能干细胞定向分化胰腺β细胞、将其他类型的体细胞重编程为胰腺β细胞，以及刺激现有胰腺β细胞的增殖和增强其功能。小分子有助于在体外生成无限数量的功能性胰腺细胞，并可进一步开发为刺激内源性胰腺再生的药物。在这里，我们提供了胰腺β细胞分化、重编程、增殖和功能方面近期主要成就的最新总结。这些研究最终将在胰腺生物学和再生领域取得重大进展。
