Department of Chemistry and Biochemistry, University of California , Los Angeles, California 90095-1569, United States.
Org Lett. 2017 Apr 7;19(7):1910-1913. doi: 10.1021/acs.orglett.7b00683. Epub 2017 Mar 24.
The nickel-catalyzed reduction of secondary and tertiary amides to give amine products is reported. The transformation is tolerant of extensive variation with respect to the amide substrate, proceeds in the presence of esters and epimerizable stereocenters, and can be used to achieve the reduction of lactams. Moreover, this methodology provides a simple tactic for accessing medicinally relevant α-deuterated amines.
报道了镍催化的仲酰胺和叔酰胺还原为胺产物的反应。该转化对酰胺底物具有广泛的适应性，在酯和可外消旋的手性中心存在下进行，并且可以用于实现内酰胺的还原。此外，该方法为获得具有药物相关性的α-氘代胺提供了一种简单的策略。
