Cools Tanne L, Struyfs Caroline, Cammue Bruno Pa, Thevissen Karin
Centre of Microbial & Plant Genetics, KU Leuven, Kasteelpark Arenberg 20, 3001 Leuven, Belgium.
Department of Plant Systems Biology, VIB, Technologiepark 927, 9052 Ghent, Belgium.
Future Microbiol. 2017 Apr;12:441-454. doi: 10.2217/fmb-2016-0181. Epub 2017 Mar 24.
Plant defensins are small, cationic peptides with a highly conserved 3D structure. They have been studied extensively in the past decades. Various biological activities have been attributed to plant defensins, such as anti-insect and antimicrobial activities, but they are also known to affect ion channels and display antitumor activity. This review focuses on the structure, biological activity and antifungal mode of action of some well-characterized plant defensins, with particular attention to their fungal membrane target(s), their induced cell death mechanisms as well as their antibiofilm activity. As plant defensins are, in general, not toxic to human cells, show in vivo efficacy and have low frequencies of resistance occurrence, they are of particular interest in the fight against fungal infections.
植物防御素是一类具有高度保守三维结构的小阳离子肽。在过去几十年中，它们得到了广泛研究。植物防御素具有多种生物学活性，如抗昆虫和抗菌活性，但也已知其会影响离子通道并具有抗肿瘤活性。本综述重点关注一些特征明确的植物防御素的结构、生物学活性和抗真菌作用模式，特别关注它们的真菌膜靶点、诱导细胞死亡机制以及抗生物膜活性。由于植物防御素一般对人类细胞无毒，具有体内疗效且耐药发生率低，因此在对抗真菌感染方面特别受关注。
