Deleruyelle Laura J
Frances Payne Bolton School of Nursing at Case Western Reserve University.
Int J Pharm Compd. 2016 Nov-Dec;20(6):447-454.
The use of compounded bioidentical hormone replacement therapy by menopausal women has become a popular alternative to traditional synthetic conjugated equine estrogen and progestin hormone replacement therapy due to safety concerns raised by recent studies. However, due to the lack of randomized, large-scale trials to evaluate the efficacy and side-effect profile of compounded bioidentical hormone replacement therapy many healthcare providers are reluctant to prescribe such therapy. The purpose of this study was to compare women's menopausal symptom relief and side effects experienced when using compounded bioidentical hormone replacement therapy and traditional hormone replacement therapy. A descriptive comparative design was used. Inferential and descriptive statistical procedures including a paired difference t-test, two-sample t-test, and f-tests (percentage, mean, standard deviation, frequency) were run on the Statistical Package for the Social Sciences. The framework used to guide this study was Lenz and Pugh's Theory of Unpleasant Symptoms. Surveys were distributed once to a convenient sample of women aged 35 and older when they dropped off or picked up their prescriptions at a pharmacy. Of the 216 surveys distributed, 70 were returned from those women taking compounded bioidentical hormone replacement therapy and 53 from traditional hormone replacement therapy. The survey contained 15 questions pertaining to age, duration of hormone replacement therapy, type and formulation of hormone replacement therapy, reasons for initiating hormone replacement therapy, symptoms before and one month after hormone replacement therapy, and side effects related to hormone replacement therapy. Included in part 1 of this series of articles was the introduction to the study conducted and the results of the literature review that was conducted for the purpose of examining the current data related to the topic of hormone replacement therapy. Part 2 provides a brief discussion on the significance of this study to nursing and provides the methods used in this study. The results of this study will be summarized in forthcoming articles in this series.
由于近期研究引发的安全担忧，绝经后女性使用复方生物同源激素替代疗法已成为传统合成共轭马雌激素和孕激素激素替代疗法的一种流行替代方案。然而，由于缺乏评估复方生物同源激素替代疗法疗效和副作用的随机、大规模试验，许多医疗服务提供者不愿开具此类疗法。本研究的目的是比较女性在使用复方生物同源激素替代疗法和传统激素替代疗法时的绝经症状缓解情况及副作用。采用了描述性比较设计。在社会科学统计软件包上运行了包括配对差异t检验、两样本t检验和f检验（百分比、均值、标准差、频率）在内的推断性和描述性统计程序。用于指导本研究的框架是伦茨和普格的不愉快症状理论。当35岁及以上的女性在药房取药或送药时，对她们进行了一次便利抽样调查。在分发的216份调查问卷中，70份来自服用复方生物同源激素替代疗法的女性，53份来自服用传统激素替代疗法的女性。该调查问卷包含15个问题，涉及年龄、激素替代疗法的持续时间、激素替代疗法的类型和配方、开始激素替代疗法的原因、激素替代疗法前和一个月后的症状以及与激素替代疗法相关的副作用。本系列文章的第1部分包括对所进行研究的介绍以及为审查与激素替代疗法主题相关的当前数据而进行的文献综述结果。第2部分简要讨论了本研究对护理的意义，并介绍了本研究中使用的方法。本研究的结果将在本系列即将发表的文章中进行总结。
