儿童常规疫苗接种后的手臂瘫痪：应用先进的分子方法评估免疫后不良事件的因果关系。
Arm Paralysis After Routine Childhood Vaccinations: Application of Advanced Molecular Methods to the Causality Assessment of an Adverse Event After Immunization.
机构信息
Department of Pediatrics, Division of Infectious Diseases, State University of New York Upstate Medical University, Golisano Children's Hospital, Syracuse.
Institute for Vaccine Safety, Department of International Health, Johns Hopkins Bloomberg School of Public Health, Baltimore, Maryland.
出版信息
J Pediatric Infect Dis Soc. 2017 Sep 1;6(3):e161-e164. doi: 10.1093/jpids/piw084.
Post-licensure surveillance for adverse events following immunizations (AEFI) can identify rare complications of vaccinations and rigorous vaccine adverse event causality assessments can help to identify possible causal relationships. We report the development of arm paralysis after varicella vaccination in a 1-year-old child. Paralysis was initially presumed to be due to vOka because of the temporal relationship between vaccination and onset of arm weakness; however, molecular studies identified wild-type varicella zoster virus VZV (WT-VZV) in the CSF, leading the authors to conclude that WT-VZV was the probable cause. This case illustrates the complexity of assessing AEFI causality, and the importance of careful and complete evaluations when determining the most likely cause of an AEFI.
疫苗接种后不良事件（AEFI）的监测可识别疫苗接种后罕见的并发症，严格的疫苗不良事件因果关系评估有助于确定可能的因果关系。我们报告了一例 1 岁儿童接种水痘疫苗后出现手臂瘫痪的病例。由于手臂无力与接种疫苗之间存在时间关系，最初推测瘫痪是由于 vOka 引起的；然而，分子研究在脑脊液中发现了野生型水痘带状疱疹病毒（WT-VZV），这使得作者得出结论，WT-VZV 是可能的病因。该病例说明了评估 AEFI 因果关系的复杂性，以及在确定 AEFI 最可能病因时进行仔细和全面评估的重要性。
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