Krupa-Burtnik Agata, Zwierzynska Ewa, Kordala Anna, Pietrzak Boguslawa
Department of Pharmacodynamics, Medical University of Lodz, Muszynskiego 1, 90-405 Lódz, Poland.
Alcohol Alcohol. 2017 May 1;52(3):282-288. doi: 10.1093/alcalc/agx003.
Zonisamide is a new anti-epileptic drug whose mechanism of action is associated with neurotransmission systems also involved in the pathogenesis of addiction. Recently, the role of memory processes and the hippocampus (Hp) is underlined in dependence. In our previous study, we determined that zonisamide decreases changes in hippocampal bioelectric activity induced by a single dose of ethanol.
This study uses a pharmaco-EEG method to examine the impact of zonisamide on the development and course of alcohol dependence in rabbits. Quantitative changes in EEG were observed in the midbrain reticular formation, Hp and frontal cortex. Zonisamide was administered p.o. once a day at dose of 30 mg/kg/day during the entire experiment. Solutions with increasing concentrations of ethanol were administered for 6 weeks, followed by a 2-week period of abstinence.
The long-term administration of ethanol caused characteristic changes in rabbit EEG recordings, which were associated with a shift toward lower frequencies resulting in a depressive effect on the bioelectric activity of selected brain structures. Co-administration of zonisamide and ethanol caused a reduction of ethanol-induced alterations. Changes in EEG recordings were different during period of abstinence and were associated with potent shift toward the high frequencies. Zonisamide significantly decreased encephalographic features of neuronal hyperactivity when administered during the abstinence.
Zonisamide decreases ethanol- and abstinence-induced changes in the EEG recordings. These effects may be a significant part of drug's mechanism of action in alcohol addiction therapy.
A pharmaco-EEG method was used to determine the influence of a new anti-epileptic drug zonisamide on the development and course of alcohol dependence in rabbits. The drug co-administered with ethanol decreased alcohol-induced changes in selected brain structures. Zonisamide also decreases abstinence-induced changes in the EEG recordings.
唑尼沙胺是一种新型抗癫痫药物，其作用机制与成瘾发病机制中涉及的神经传递系统有关。最近，记忆过程和海马体（Hp）在成瘾中的作用得到了强调。在我们之前的研究中，我们确定唑尼沙胺可减少单剂量乙醇诱导的海马体生物电活动变化。
本研究采用药物脑电图方法，研究唑尼沙胺对家兔酒精依赖发展和病程的影响。观察中脑网状结构、Hp和额叶皮质脑电图的定量变化。在整个实验过程中，每天口服一次唑尼沙胺，剂量为30mg/kg/天。给予浓度递增的乙醇溶液6周，随后禁欲2周。
长期给予乙醇会导致家兔脑电图记录出现特征性变化，这与频率向低频转移有关，从而对选定脑结构的生物电活动产生抑制作用。唑尼沙胺与乙醇联合给药可减少乙醇诱导的变化。在禁欲期间，脑电图记录的变化不同，且与向高频的显著转移有关。在禁欲期间给予唑尼沙胺可显著降低神经元活动亢进的脑电图特征。
唑尼沙胺可减少乙醇和禁欲诱导的脑电图记录变化。这些作用可能是该药物在酒精成瘾治疗中作用机制的重要组成部分。
采用药物脑电图方法确定新型抗癫痫药物唑尼沙胺对家兔酒精依赖发展和病程的影响。该药物与乙醇联合给药可减少乙醇诱导的选定脑结构变化。唑尼沙胺还可减少禁欲诱导的脑电图记录变化。
